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10.1186/s41065-020-00168-4 http://scihub22266oqcxt.onion/10.1186/s41065-020-00168-4 33397514!7781406!33397514     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33397514.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Hereditas 2021 ; 158 (1): 4 Nephropedia Template TP {{tp|p=33397514|t=2021. Mediators of SARS-CoV-2 entry are preferentially enriched in cardiomyocytes |pdf=|usr=}}{{33397514}} gab.com Text Mediators of SARS-CoV-2 entry are preferentially enriched in cardiomyocytes JO: Hereditas http://www.kidney.de/pget.php?&tw=1&pmid=33397514 #FOAvip BACKGROUND: The coronavirus disease 2019 (COVID-19) has spread rapidly around the world. In addition to common respiratory symptoms such as cough and fever, some patients also have cardiac injury, however, the mechanism of cardiac injury is not clear. In this study, we analyzed the RNA expression atlases of angiotensin-converting enzyme 2(ACE2), cathepsin B (CTSB) and cathepsin L (CTSL) in the human embryonic heart at single-cell resolution. RESULTS: The results showed that ACE2 was preferentially enriched in cardiomyocytes. Interestingly, serine protease transmembrane serine protease 2 (TMPRSS2) had less expression in cardiomyocytes, but CTSB and CTSL, which belonged to cell protease, could be found to be enriched in cardiomyocytes. The results of enrichment analysis showed that differentially expressed genes (DEGs) in ACE2-positive cardiomyocytes were mainly enriched in the processes of cardiac muscle contraction, regulation of cardiac conduction, mitochondrial respiratory chain, ion channel binding, adrenergic signaling in cardiomyocytes and viral transcription. CONCLUSIONS: Our study suggests that both atrial and ventricular cardiomyocytes are potentially susceptible to severe acute respiratory syndrome coronavirus-2(SARS-CoV-2), and SARS-CoV-2 may enter ventricular cardiomyocytes using CTSB/CTSL for S protein priming. This may be the partial cellular mechanism of cardiac injury in patients with COVID-19. Twit Text FOAVip Mediators of SARS-CoV-2 entry are preferentially enriched in cardiomyocytes ????Hereditas http://www.kidney.de/pget.php?&tw=1&pmid=33397514 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33397514 #FOAvip English Wikipedia <ref>{{Cite pmid|33397514}}</ref> Mediators of SARS-CoV-2 entry are preferentially enriched in cardiomyocytes #MMPMID33397514 Yang J; Chen T; Zhou Y Hereditas 2021[Jan]; 158 (1): 4 PMID33397514show ga BACKGROUND: The coronavirus disease 2019 (COVID-19) has spread rapidly around the world. In addition to common respiratory symptoms such as cough and fever, some patients also have cardiac injury, however, the mechanism of cardiac injury is not clear. In this study, we analyzed the RNA expression atlases of angiotensin-converting enzyme 2(ACE2), cathepsin B (CTSB) and cathepsin L (CTSL) in the human embryonic heart at single-cell resolution. RESULTS: The results showed that ACE2 was preferentially enriched in cardiomyocytes. Interestingly, serine protease transmembrane serine protease 2 (TMPRSS2) had less expression in cardiomyocytes, but CTSB and CTSL, which belonged to cell protease, could be found to be enriched in cardiomyocytes. The results of enrichment analysis showed that differentially expressed genes (DEGs) in ACE2-positive cardiomyocytes were mainly enriched in the processes of cardiac muscle contraction, regulation of cardiac conduction, mitochondrial respiratory chain, ion channel binding, adrenergic signaling in cardiomyocytes and viral transcription. CONCLUSIONS: Our study suggests that both atrial and ventricular cardiomyocytes are potentially susceptible to severe acute respiratory syndrome coronavirus-2(SARS-CoV-2), and SARS-CoV-2 may enter ventricular cardiomyocytes using CTSB/CTSL for S protein priming. This may be the partial cellular mechanism of cardiac injury in patients with COVID-19. |*Gene Expression Regulation, Developmental[MESH] |Angiotensin-Converting Enzyme 2/genetics[MESH] |COVID-19/epidemiology/*prevention & control/virology[MESH] |Cathepsin B/genetics[MESH] |Cathepsin L/genetics[MESH] |Gene Ontology[MESH] |Heart/*embryology[MESH] |Humans[MESH] |Myocytes, Cardiac/cytology/*metabolism/virology[MESH] |Pandemics[MESH] |SARS-CoV-2/*genetics/physiology[MESH] |Serine Endopeptidases/genetics[MESH] |Signal Transduction/genetics[MESH]Mediators of SARS-CoV-2 entry are preferentially enriched in cardiomyo(epmc).pdf DeepDyve Pubget Overpricing