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10.2174/1389557521999210101224058 http://scihub22266oqcxt.onion/10.2174/1389557521999210101224058 33397258!ä!33397258 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mini+Rev+Med+Chem 2021 ; 21 (13): 1770-1795 Nephropedia Template TP {{tp|p=33397258|t=2021. A Therapeutic Journey of 5-Pyrazolones as a Versatile Scaffold: A Review |pdf=|usr=}}{{33397258}} gab.com Text A Therapeutic Journey of 5-Pyrazolones as a Versatile Scaffold: A Review JO: Mini Rev Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=33397258 #FOAvip A sizeable proportion of currently marketed drugs come from heterocycles. The heterocyclic moiety 5-pyrazolone is well known five-membered ring containing nitrogen. Derivatives of this wonder nucleus have exhibited activities as diverse as antimicrobial, anti-inflammatory, analgesic, antidepressant, anticonvulsant, antidiabetic, antihyperlipidemic, antiviral, antitubercular, antioxidant, anticancer and antiviral, including action against severe acute respiratory syndrome (SARS) or 3C protease inhibitor. A number of drugs based on this motif have already made it to the market. Standard texts and literature on medicinal chemistry cite different approaches for the synthesis of 5- pyrazolones. The present review provides an insight view to 5-pyrazolone synthesis, their biological profile and structure-activity relationship studies. Twit Text FOAVip A Therapeutic Journey of 5-Pyrazolones as a Versatile Scaffold: A Review ????Mini Rev Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=33397258 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33397258 #FOAvip English Wikipedia <ref>{{Cite pmid|33397258}}</ref> A Therapeutic Journey of 5-Pyrazolones as a Versatile Scaffold: A Review #MMPMID33397258 Sharma R; Chawla PA; Chawla V; Verma R; Nawal N; Gupta V Mini Rev Med Chem 2021[]; 21 (13): 1770-1795 PMID33397258show ga A sizeable proportion of currently marketed drugs come from heterocycles. The heterocyclic moiety 5-pyrazolone is well known five-membered ring containing nitrogen. Derivatives of this wonder nucleus have exhibited activities as diverse as antimicrobial, anti-inflammatory, analgesic, antidepressant, anticonvulsant, antidiabetic, antihyperlipidemic, antiviral, antitubercular, antioxidant, anticancer and antiviral, including action against severe acute respiratory syndrome (SARS) or 3C protease inhibitor. A number of drugs based on this motif have already made it to the market. Standard texts and literature on medicinal chemistry cite different approaches for the synthesis of 5- pyrazolones. The present review provides an insight view to 5-pyrazolone synthesis, their biological profile and structure-activity relationship studies. |*Drug Design[MESH] |Humans[MESH] |Molecular Structure[MESH] |Pharmaceutical Preparations/chemistry[MESH] |Pyrazolones/chemical synthesis/*chemistry/*pharmacology[MESH]A Therapeutic Journey of 5-Pyrazolones as a Versatile Scaffold: A Revi(epmc).pdf DeepDyve Pubget Overpricing