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10.3390/v13010044 http://scihub22266oqcxt.onion/10.3390/v13010044 33396578!7824252!33396578     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Viruses 2020 ; 13 (1): ä Nephropedia Template TP {{tp|p=33396578|t=2020. Interferon-alpha2b Treatment for COVID-19 Is Associated with Improvements in Lung Abnormalities |pdf=|usr=}}{{33396578}} gab.com Text Interferon-alpha2b Treatment for COVID-19 Is Associated with Improvements in Lung Abnormalities JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=33396578 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes coronavirus disease 2019 (COVID-19), a lung disease that may progress to systemic organ involvement and in some cases, death. The identification of the earliest predictors of progressive lung disease would allow for therapeutic intervention in those cases. In an earlier clinical study, individuals with moderate COVID-19 were treated with either arbidol (ARB) or inhaled interferon (IFN)-alpha2b +/-ARB. IFN treatment resulted in accelerated viral clearance from the upper airways and in a reduction in the circulating levels of the inflammatory biomarkers IL-6 and C-reactive protein (CRP). We have extended the analysis of this study cohort to determine whether IFN treatment had a direct effect on virus-induced lung abnormalities and also to ascertain whether any clinical or immune parameters are associated with worsening of lung abnormalities. Evidence is provided that IFN-alpha2b treatment limits the development of lung abnormalities associated with COVID-19, as assessed by CT images. Clinical predictors associated with worsening of lung abnormalities include low CD8+ T cell numbers, low levels of circulating albumin, high numbers of platelets, and higher levels of circulating interleukin (IL)-10, IL-6, and C-reactive protein (CRP). Notably, in this study cohort, IFN treatment resulted in a higher percentage of CD8+ T cells, lower tumor necrosis factor (TNF)-alpha levels and, as reported earlier, lower IL-6 levels. Independent of treatment, age and circulating levels of albumin and CRP emerged as the strongest predictors of the severity of lung abnormalities. Twit Text FOAVip Interferon-alpha2b Treatment for COVID-19 Is Associated with Improvements in Lung Abnormalities ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=33396578 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33396578 #FOAvip English Wikipedia <ref>{{Cite pmid|33396578}}</ref> Interferon-alpha2b Treatment for COVID-19 Is Associated with Improvements in Lung Abnormalities #MMPMID33396578 Zhou Q; MacArthur MR; He X; Wei X; Zarin P; Hanna BS; Wang ZH; Xiang X; Fish EN Viruses 2020[Dec]; 13 (1): ä PMID33396578show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes coronavirus disease 2019 (COVID-19), a lung disease that may progress to systemic organ involvement and in some cases, death. The identification of the earliest predictors of progressive lung disease would allow for therapeutic intervention in those cases. In an earlier clinical study, individuals with moderate COVID-19 were treated with either arbidol (ARB) or inhaled interferon (IFN)-alpha2b +/-ARB. IFN treatment resulted in accelerated viral clearance from the upper airways and in a reduction in the circulating levels of the inflammatory biomarkers IL-6 and C-reactive protein (CRP). We have extended the analysis of this study cohort to determine whether IFN treatment had a direct effect on virus-induced lung abnormalities and also to ascertain whether any clinical or immune parameters are associated with worsening of lung abnormalities. Evidence is provided that IFN-alpha2b treatment limits the development of lung abnormalities associated with COVID-19, as assessed by CT images. Clinical predictors associated with worsening of lung abnormalities include low CD8+ T cell numbers, low levels of circulating albumin, high numbers of platelets, and higher levels of circulating interleukin (IL)-10, IL-6, and C-reactive protein (CRP). Notably, in this study cohort, IFN treatment resulted in a higher percentage of CD8+ T cells, lower tumor necrosis factor (TNF)-alpha levels and, as reported earlier, lower IL-6 levels. Independent of treatment, age and circulating levels of albumin and CRP emerged as the strongest predictors of the severity of lung abnormalities. |*COVID-19 Drug Treatment[MESH] |Administration, Inhalation[MESH] |Antiviral Agents/administration & dosage/*therapeutic use[MESH] |Biomarkers/blood[MESH] |C-Reactive Protein[MESH] |CD8-Positive T-Lymphocytes[MESH] |COVID-19/physiopathology[MESH] |China[MESH] |Cohort Studies[MESH] |Cytokines/immunology[MESH] |Drug Therapy, Combination[MESH] |Humans[MESH] |Indoles/administration & dosage/therapeutic use[MESH] |Interferon alpha-2[MESH] |Interferon-alpha/administration & dosage/*therapeutic use[MESH] |Interleukin-10[MESH] |Interleukin-6[MESH] |Lung/*abnormalities/diagnostic imaging/pathology[MESH]Interferon-alpha2b Treatment for COVID-19 Is Associated with Improveme(epmc).pdf DeepDyve Pubget Overpricing