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10.3390/v13010054

http://scihub22266oqcxt.onion/10.3390/v13010054
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33396343!7824305!33396343
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suck abstract from ncbi


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pmid33396343      Viruses 2020 ; 13 (1): ä
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  • Lead SARS-CoV-2 Candidate Vaccines: Expectations from Phase III Trials and Recommendations Post-Vaccine Approval #MMPMID33396343
  • Tumban E
  • Viruses 2020[Dec]; 13 (1): ä PMID33396343show ga
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted primarily through respiratory droplets/aerosols and it causes COVID-19. The virus infects epithelial cells by using the spike protein on its surface to bind to angiotensin-converting enzyme 2 receptor on the cells. Thus, candidate vaccines targeting the spike protein are currently being developed to prevent against infections. Approximately 44 SARS-CoV-2 candidate vaccines are in clinical trials (phase I-III) and an additional 164 candidates are in preclinical stages. The efficacy data from phase I/II trials of lead candidate vaccines look very promising with virus-neutralizing geometric mean antibody titers in the range of 16.6-3906. Most recently, two SARS-CoV-2 candidate vaccines, BNT162b2 and mRNA-1273, have been granted the first emergency use authorization (EUA) in the U.S.; BNT162b2 has also been granted an EUA in the United Kingdom, Canada, and in the European Union. This review assesses whether SARS-CoV-2 candidate vaccines (with approved EUA or in phase III trials) meet the criteria for an ideal SARS-CoV-2 vaccine. The review concludes with expectations from phase III trials and recommendations for phase IV studies (post-vaccine approval).
  • |*COVID-19 Vaccines[MESH]
  • |*Drug Approval[MESH]
  • |*SARS-CoV-2[MESH]
  • |2019-nCoV Vaccine mRNA-1273[MESH]
  • |Antibodies, Neutralizing/immunology[MESH]
  • |BNT162 Vaccine[MESH]
  • |COVID-19/*prevention & control[MESH]
  • |Canada[MESH]
  • |Clinical Trials as Topic[MESH]
  • |Clinical Trials, Phase III as Topic[MESH]
  • |Clinical Trials, Phase IV as Topic[MESH]
  • |Europe[MESH]
  • |Humans[MESH]
  • |Spike Glycoprotein, Coronavirus/immunology[MESH]
  • |United Kingdom[MESH]
  • |United States[MESH]
  • |Vaccines, Synthetic[MESH]


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