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10.1093/infdis/jiab002 http://scihub22266oqcxt.onion/10.1093/infdis/jiab002 33395484!7799041!33395484     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Infect+Dis 2021 ; 224 (5): 821-830 Nephropedia Template TP {{tp|p=33395484|t=2021. Tropism of SARS-CoV-2, SARS-CoV, and Influenza Virus in Canine Tissue Explants |pdf=|usr=}}{{33395484}} gab.com Text Tropism of SARS-CoV-2, SARS-CoV, and Influenza Virus in Canine Tissue Explants JO: J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=33395484 #FOAvip BACKGROUND: Human spillovers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to dogs and the emergence of a highly contagious avian-origin H3N2 canine influenza virus have raised concerns on the role of dogs in the spread of SARS-CoV-2 and their susceptibility to existing human and avian influenza viruses, which might result in further reassortment. METHODS: We systematically studied the replication kinetics of SARS-CoV-2, SARS-CoV, influenza A viruses of H1, H3, H5, H7, and H9 subtypes, and influenza B viruses of Yamagata-like and Victoria-like lineages in ex vivo canine nasal cavity, soft palate, trachea, and lung tissue explant cultures and examined ACE2 and sialic acid (SA) receptor distribution in these tissues. RESULTS: There was limited productive replication of SARS-CoV-2 in canine nasal cavity and SARS-CoV in canine nasal cavity, soft palate, and lung, with unexpectedly high ACE2 levels in canine nasal cavity and soft palate. Canine tissues were susceptible to a wide range of human and avian influenza viruses, which matched with the abundance of both human and avian SA receptors. CONCLUSIONS: Existence of suitable receptors and tropism for the same tissue foster virus adaptation and reassortment. Continuous surveillance in dog populations should be conducted given the many chances for spillover during outbreaks. Twit Text FOAVip Tropism of SARS-CoV-2, SARS-CoV, and Influenza Virus in Canine Tissue Explants ????J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=33395484 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33395484 #FOAvip English Wikipedia <ref>{{Cite pmid|33395484}}</ref> Tropism of SARS-CoV-2, SARS-CoV, and Influenza Virus in Canine Tissue Explants #MMPMID33395484 Bui CHT; Yeung HW; Ho JCW; Leung CYH; Hui KPY; Perera RAPM; Webby RJ; Schultz-Cherry SL; Nicholls JM; Peiris JSM; Chan MCW J Infect Dis 2021[Sep]; 224 (5): 821-830 PMID33395484show ga BACKGROUND: Human spillovers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to dogs and the emergence of a highly contagious avian-origin H3N2 canine influenza virus have raised concerns on the role of dogs in the spread of SARS-CoV-2 and their susceptibility to existing human and avian influenza viruses, which might result in further reassortment. METHODS: We systematically studied the replication kinetics of SARS-CoV-2, SARS-CoV, influenza A viruses of H1, H3, H5, H7, and H9 subtypes, and influenza B viruses of Yamagata-like and Victoria-like lineages in ex vivo canine nasal cavity, soft palate, trachea, and lung tissue explant cultures and examined ACE2 and sialic acid (SA) receptor distribution in these tissues. RESULTS: There was limited productive replication of SARS-CoV-2 in canine nasal cavity and SARS-CoV in canine nasal cavity, soft palate, and lung, with unexpectedly high ACE2 levels in canine nasal cavity and soft palate. Canine tissues were susceptible to a wide range of human and avian influenza viruses, which matched with the abundance of both human and avian SA receptors. CONCLUSIONS: Existence of suitable receptors and tropism for the same tissue foster virus adaptation and reassortment. Continuous surveillance in dog populations should be conducted given the many chances for spillover during outbreaks. |Angiotensin-Converting Enzyme 2/metabolism[MESH] |Animals[MESH] |COVID-19/metabolism/*virology[MESH] |Dogs[MESH] |Humans[MESH] |Influenza A virus/*physiology[MESH] |Influenza, Human/metabolism/virology[MESH] |Lung/metabolism/*virology[MESH] |Nasal Cavity/metabolism/*virology[MESH] |Orthomyxoviridae Infections/metabolism/virology[MESH] |SARS-CoV-2/*physiology[MESH] |Trachea/metabolism/*virology[MESH]Tropism of SARS-CoV-2, SARS-CoV, and Influenza Virus in Canine Tissue (epmc).pdf DeepDyve Pubget Overpricing