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Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Virol+Sin 2020 ; 35 (6): 713-724 Nephropedia Template TP
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Human Monoclonal Antibodies: On the Menu of Targeted Therapeutics Against COVID-19 #MMPMID33394351
Chen J; Huang R; Nie Y; Wen X; Wu Y
Virol Sin 2020[Dec]; 35 (6): 713-724 PMID33394351show ga
Coronavirus disease 2019 (COVID-19), reminiscent of the severe acute respiratory syndrome (SARS) outbreak in 2003, has been a tragic disaster to people all over the world. As there is no specific drug for COVID-19, neutralizing antibodies are attracting more and more attention as one of the most effective means to combat the pandemic. Here, we introduced the etiological and serological characteristics of COVID-19, discussed the current stage of development of human monoclonal antibodies against SARS-CoV-2 and summarized the antigenic epitopes in the S glycoprotein, which may deepen the understanding of the profile of immune recognition and response against SARS-CoV-2 and provide insight for the design of effective vaccines and antibody-based therapies.