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10.1007/s10875-020-00941-0

http://scihub22266oqcxt.onion/10.1007/s10875-020-00941-0
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33394320!7780601!33394320
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suck abstract from ncbi


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pmid33394320      J+Clin+Immunol 2021 ; 41 (3): 526-535
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  • Distinctive Features of Kawasaki Disease Following SARS-CoV-2 Infection: a Controlled Study in Paris, France #MMPMID33394320
  • Toubiana J; Cohen JF; Brice J; Poirault C; Bajolle F; Curtis W; Moulin F; Matczak S; Leruez M; Casanova JL; Chalumeau M; Taylor M; Allali S
  • J Clin Immunol 2021[Apr]; 41 (3): 526-535 PMID33394320show ga
  • BACKGROUND: An outbreak of multisystem inflammatory syndrome in children, including Kawasaki disease (KD), emerged during COVID-19 pandemic. We explored whether Kawasaki-like disease (KD), when associated with confirmed SARS-CoV-2 infection, has specific characteristics. METHODS: We included children and adolescents with KD criteria admitted in the department of general pediatrics of a university hospital in Paris, France, between January 1, 2018, and May 26, 2020. The incidence of KD was compared between the outbreak and a pre-outbreak control period (January 1, 2018, to April 25). Characteristics of patients with positive SARS-CoV-2 testing (KD-SARS-CoV-2) were compared to those of the pre-outbreak period (classic KD). RESULTS: A total of 30 and 59 children with KD were admitted during the outbreak and pre-outbreak periods, respectively (incidence ratio 13.2 [8.3-21.0]). During the outbreak, 23/30 (77%) children were diagnosed as KD-SARS-CoV-2. When compared with patients with classic KD, those with KD-SARS-CoV-2 were more frequently of sub-Saharan African ancestry (OR 4.4 [1.6-12.6]) and older (median 8.2 vs. 4.0 years, p < 0.001), had more often initial gastrointestinal (OR 84 [4.9-1456]) and neurological (OR 7.3 [1.9-27.7] manifestations, and shock syndrome (OR 13.7 [4.2-45.1]). They had significantly higher CRP and ferritin levels. Noticeably, they had more frequently myocarditis (OR 387 [38-3933]). CONCLUSIONS: Children and adolescents with KD-SARS-CoV-2 have specific features when compared with those with classic KD. These findings should raise awareness and facilitate the study of their pathogenesis.
  • |*SARS-CoV-2[MESH]
  • |Adolescent[MESH]
  • |COVID-19/*complications[MESH]
  • |Child[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Mucocutaneous Lymph Node Syndrome/epidemiology/*etiology[MESH]
  • |Paris/epidemiology[MESH]


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