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10.1007/s00134-020-06328-4

http://scihub22266oqcxt.onion/10.1007/s00134-020-06328-4
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suck abstract from ncbi


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pmid33392642      Intensive+Care+Med 2021 ; 47 (2): 199-207
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  • Ultrasound assessment of pulmonary fibroproliferative changes in severe COVID-19: a quantitative correlation study with histopathological findings #MMPMID33392642
  • de Almeida Monteiro RA; Duarte-Neto AN; Ferraz da Silva LF; de Oliveira EP; do Nascimento ECT; Mauad T; Saldiva PHDN; Dolhnikoff M
  • Intensive Care Med 2021[Feb]; 47 (2): 199-207 PMID33392642show ga
  • PURPOSE: This study was designed to evaluate the usefulness of lung ultrasound (LUS) imaging to characterize the progression and severity of lung damage in cases of COVID-19. METHODS: We employed a set of combined ultrasound parameters and histopathological images obtained simultaneously in 28 patients (15 women, 0.6-83 years) with fatal COVID-19 submitted to minimally invasive autopsies, with different times of disease evolution from initial symptoms to death (3-37 days, median 18 days). For each patient, we analysed eight post-mortem LUS parameters and the proportion of three histological patterns (normal lung, exudative diffuse alveolar damage [DAD] and fibroproliferative DAD) in eight different lung regions. The relationship between histopathological and post-mortem ultrasonographic findings was assessed using various statistical approaches. RESULTS: Statistically significant positive correlations were observed between fibroproliferative DAD and peripheral consolidation (coefficient 0.43, p = 0.02) and pulmonary consolidation (coefficient 0.51, p = 0.005). A model combining age, time of evolution, sex and ultrasound score predicted reasonably well (r = 0.66) the proportion of pulmonary parenchyma with fibroproliferative DAD. CONCLUSION: The present study adds information to previous studies related to the use of LUS as a tool to assess the severity of acute pulmonary damage. We provide a histological background that supports the concept that LUS can be used to characterize the progression and severity of lung damage in severe COVID-19.
  • |*Ultrasonography[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19/*diagnostic imaging/pathology[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Correlation of Data[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Lung/*diagnostic imaging/pathology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]


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