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10.1002/jev2.12050

http://scihub22266oqcxt.onion/10.1002/jev2.12050
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33391636!7769856!33391636
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suck abstract from ncbi


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pmid33391636      J+Extracell+Vesicles 2020 ; 10 (2): e12050
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  • Extracellular vesicles containing ACE2 efficiently prevent infection by SARS-CoV-2 Spike protein-containing virus #MMPMID33391636
  • Cocozza F; Nevo N; Piovesana E; Lahaye X; Buchrieser J; Schwartz O; Manel N; Tkach M; Thery C; Martin-Jaular L
  • J Extracell Vesicles 2020[Dec]; 10 (2): e12050 PMID33391636show ga
  • SARS-CoV-2 entry is mediated by binding of the spike protein (S) to the surface receptor ACE2 and subsequent priming by host TMPRSS2 allowing membrane fusion. Here, we produced extracellular vesicles (EVs) exposing ACE2 and demonstrate that ACE2-EVs are efficient decoys for SARS-CoV-2 S protein-containing lentivirus. Reduction of infectivity positively correlates with the level of ACE2, is much more efficient than with soluble ACE2 and further enhanced by the inclusion of TMPRSS2.
  • |Angiotensin-Converting Enzyme 2/*chemistry/physiology[MESH]
  • |COVID-19/*prevention & control/*virology[MESH]
  • |Caco-2 Cells/virology[MESH]
  • |Cell Line/virology[MESH]
  • |Extracellular Vesicles/metabolism[MESH]
  • |Humans[MESH]
  • |Lentivirus[MESH]
  • |Receptors, Virus/metabolism[MESH]
  • |SARS-CoV-2[MESH]
  • |Serine Endopeptidases/metabolism[MESH]
  • |Spike Glycoprotein, Coronavirus[MESH]


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