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Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Oral+Microbiol 2020 ; 13 (1): 1858002 Nephropedia Template TP
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Performance of at-home self-collected saliva and nasal-oropharyngeal swabs in the surveillance of COVID-19 #MMPMID33391631
Braz-Silva PH; Mamana AC; Romano CM; Felix AC; de Paula AV; Fereira NE; Buss LF; Tozetto-Mendoza TR; Caixeta RAV; Leal FE; Grespan RMZ; Bizario JCS; Ferraz ABC; Sapkota D; Giannecchini S; To KK; Doglio A; Mendes-Correa MC
J Oral Microbiol 2020[Dec]; 13 (1): 1858002 PMID33391631show ga
Background: SARS-CoV-2 quickly spreads in the worldwide population, imposing social restrictions to control the infection, being the massive testing another essential strategy to break the chain of transmission. Aim: To compare the performance of at-home self-collected samples - saliva and combined nasal-oropharyngeal swabs (NOP) - for SARS-CoV-2 detection in a telemedicine platform for COVID-19 surveillance. Material and methods: We analyzed 201 patients who met the criteria of suspected COVID-19. NOP sampling was combined (nostrils and oropharynx) and saliva collected using a cotton pad device. Detection of SARS-COV-2 was performed by using the Altona RealStar(R) SARS-CoV-2 RT-PCR Kit 1.0. Results: There was an overall significant agreement (kappa coefficient value of 0.58) between saliva and NOP. Considering results in either sample, 70 patients positive for SARS-CoV-2 were identified, with 52/70 being positive in NOP and 55/70 in saliva. This corresponds to sensitivities of 74.2% (95% CI; 63.7% to 83.1%) for NOP and 78.6% (95% CI; 67.6% to 86.6%) for saliva. Conclusion: Our data show the feasibility of using at-home self-collected samples (especially saliva), as an adequate alternative for SARS-CoV-2 detection. This new approach of testing can be useful to develop strategies for COVID-19 surveillance and for guiding public health decisions.