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10.5582/ddt.2020.03097 http://scihub22266oqcxt.onion/10.5582/ddt.2020.03097 33390567!ä!33390567 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33390567&cmd=llinks): Failed to open stream: HTTP request failed! 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Analytical methods for the determination of remdesivir as a promising antiviral candidate drug for the COVID-19 pandemic |pdf=|usr=}}{{33390567}} gab.com Text Analytical methods for the determination of remdesivir as a promising antiviral candidate drug for the COVID-19 pandemic JO: Drug Discov Ther http://www.kidney.de/pget.php?&tw=1&pmid=33390567 #FOAvip Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is undoubtedly the most challenging pandemic in the current century. A total of 73,953,702 confirmed cases of COVID-19 and 1,644,416 deaths were reported globally up to December 17, 2020. Therefore, in the absence of a safe and effective vaccine, it is urgent to identify a novel antiviral drug to effectively treat patients with COVID-19. On October 22, the U.S. Food and Drug Administration approved remdesivir, a nucleotide analog prodrug with broad antiviral activity, for adults and children (12 years of age and older and weighing at least 40 kg) who need to be admitted to hospital for covid-19 treatment. In order to monitor the optimization of patient clinical response profile, as well as address the challenges associated with remdesivir metabolism, highly sensitive, selective and accurate analytical methods are necessary. This review clearly covers all the analytical methods developed for the identification and quantitative determination of remdesivir and its metabolites in biological matrices, which helps the researchers in developing new methods for the analysis of remdesivir by considering the pros and cons of the previously reported methods. Twit Text FOAVip Analytical methods for the determination of remdesivir as a promising antiviral candidate drug for the COVID-19 pandemic ????Drug Discov Ther http://www.kidney.de/pget.php?&tw=1&pmid=33390567 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33390567 #FOAvip English Wikipedia <ref>{{Cite pmid|33390567}}</ref> Analytical methods for the determination of remdesivir as a promising antiviral candidate drug for the COVID-19 pandemic #MMPMID33390567 Pashaei Y Drug Discov Ther 2021[Jan]; 14 (6): 273-281 PMID33390567show ga Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is undoubtedly the most challenging pandemic in the current century. A total of 73,953,702 confirmed cases of COVID-19 and 1,644,416 deaths were reported globally up to December 17, 2020. Therefore, in the absence of a safe and effective vaccine, it is urgent to identify a novel antiviral drug to effectively treat patients with COVID-19. On October 22, the U.S. Food and Drug Administration approved remdesivir, a nucleotide analog prodrug with broad antiviral activity, for adults and children (12 years of age and older and weighing at least 40 kg) who need to be admitted to hospital for covid-19 treatment. In order to monitor the optimization of patient clinical response profile, as well as address the challenges associated with remdesivir metabolism, highly sensitive, selective and accurate analytical methods are necessary. This review clearly covers all the analytical methods developed for the identification and quantitative determination of remdesivir and its metabolites in biological matrices, which helps the researchers in developing new methods for the analysis of remdesivir by considering the pros and cons of the previously reported methods. |*COVID-19 Drug Treatment[MESH] |Adenosine Monophosphate/*analogs & derivatives/analysis/pharmacokinetics[MESH] |Alanine/*analogs & derivatives/analysis/pharmacokinetics[MESH] |Antiviral Agents/*analysis/pharmacokinetics[MESH] |COVID-19/diagnosis/virology[MESH] |Drug Monitoring/*methods[MESH] |Humans[MESH] |Predictive Value of Tests[MESH]Analytical methods for the determination of remdesivir as a promising (epmc).pdf DeepDyve Pubget Overpricing