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10.2169/internalmedicine.6010-20

http://scihub22266oqcxt.onion/10.2169/internalmedicine.6010-20
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33390490!7946515!33390490
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suck abstract from ncbi


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pmid33390490      Intern+Med 2021 ; 60 (4): 639-643
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  • Immediate Amelioration of Severe Respiratory Distress in Sjogren s Syndrome with COVID-19 Treated with a Single Dose of Off-label Tocilizumab #MMPMID33390490
  • Kataoka H; Kodama F; Tomita T; Kondo M; Nagasaka A; Nishikawa S; Mukai M
  • Intern Med 2021[Feb]; 60 (4): 639-643 PMID33390490show ga
  • The coronavirus disease 2019 (COVID-19) pandemic has become an urgent global health issue. An older age and underlying conditions, such as diabetes, have been reported as risk factors, but whether or not autoimmune diseases increase the risk remains unknown. An 85-year-old man with Sjogren's syndrome developed a severe COVID-19 infection that required oxygen supplementation. After discussing the goals of care with him and his wife, off-label tocilizumab was given concomitantly, resulting in a rapid improvement in his symptoms and respiratory failure. This patient represents a supplementary case confirming the efficacy and safety of tocilizumab for COVID-19 in elderly patients with autoimmune diseases.
  • |*Off-Label Use[MESH]
  • |Adrenal Cortex Hormones/therapeutic use[MESH]
  • |Aged, 80 and over[MESH]
  • |Anti-Inflammatory Agents/therapeutic use[MESH]
  • |Antibodies, Monoclonal, Humanized/*therapeutic use[MESH]
  • |COVID-19/*complications/immunology[MESH]
  • |Cytokine Release Syndrome[MESH]
  • |Drug Therapy, Combination[MESH]
  • |Dyspnea/etiology[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Pandemics[MESH]
  • |Respiratory Distress Syndrome/*drug therapy/etiology[MESH]
  • |Respiratory Insufficiency/drug therapy[MESH]
  • |SARS-CoV-2[MESH]


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