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10.1007/s43440-020-00195-y http://scihub22266oqcxt.onion/10.1007/s43440-020-00195-y 33389725!7778723!33389725     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33389725&cmd=llinks): Failed to open stream: HTTP request failed! 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Ivermectin as a potential drug for treatment of COVID-19: an in-sync review with clinical and computational attributes |pdf=|usr=}}{{33389725}} gab.com Text Ivermectin as a potential drug for treatment of COVID-19: an in-sync review with clinical and computational attributes JO: Pharmacol Rep http://www.kidney.de/pget.php?&tw=1&pmid=33389725 #FOAvip INTRODUCTION: COVID-19 cases are on surge; however, there is no efficient treatment or vaccine that can be used for its management. Numerous clinical trials are being reviewed for use of different drugs, biologics, and vaccines in COVID-19. A much empirical approach will be to repurpose existing drugs for which pharmacokinetic and safety data are available, because this will facilitate the process of drug development. The article discusses the evidence available for the use of Ivermectin, an anti-parasitic drug with antiviral properties, in COVID-19. METHODS: A rational review of the drugs was carried out utilizing their clinically significant attributes. A more thorough understanding was met by virtual embodiment of the drug structure and realizable viral targets using artificial intelligence (AI)-based and molecular dynamics (MD)-simulation-based study. CONCLUSION: Certain studies have highlighted the significance of ivermectin in COVID-19; however, it requires evidences from more Randomised Controlled Trials (RCTs) and dose- response studies to support its use. In silico-based analysis of ivermectin's molecular interaction specificity using AI and classical mechanics simulation-based methods indicates positive interaction of ivermectin with viral protein targets, which is leading for SARS-CoV 2 N-protein NTD (nucleocapsid protein N-terminal domain). Twit Text FOAVip Ivermectin as a potential drug for treatment of COVID-19: an in-sync review with clinical and computational attributes ????Pharmacol Rep http://www.kidney.de/pget.php?&tw=1&pmid=33389725 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33389725 #FOAvip English Wikipedia <ref>{{Cite pmid|33389725}}</ref> Ivermectin as a potential drug for treatment of COVID-19: an in-sync review with clinical and computational attributes #MMPMID33389725 Kaur H; Shekhar N; Sharma S; Sarma P; Prakash A; Medhi B Pharmacol Rep 2021[Jun]; 73 (3): 736-749 PMID33389725show ga INTRODUCTION: COVID-19 cases are on surge; however, there is no efficient treatment or vaccine that can be used for its management. Numerous clinical trials are being reviewed for use of different drugs, biologics, and vaccines in COVID-19. A much empirical approach will be to repurpose existing drugs for which pharmacokinetic and safety data are available, because this will facilitate the process of drug development. The article discusses the evidence available for the use of Ivermectin, an anti-parasitic drug with antiviral properties, in COVID-19. METHODS: A rational review of the drugs was carried out utilizing their clinically significant attributes. A more thorough understanding was met by virtual embodiment of the drug structure and realizable viral targets using artificial intelligence (AI)-based and molecular dynamics (MD)-simulation-based study. CONCLUSION: Certain studies have highlighted the significance of ivermectin in COVID-19; however, it requires evidences from more Randomised Controlled Trials (RCTs) and dose- response studies to support its use. In silico-based analysis of ivermectin's molecular interaction specificity using AI and classical mechanics simulation-based methods indicates positive interaction of ivermectin with viral protein targets, which is leading for SARS-CoV 2 N-protein NTD (nucleocapsid protein N-terminal domain). |*COVID-19 Drug Treatment[MESH] |Animals[MESH] |Antiparasitic Agents/pharmacology/therapeutic use[MESH] |Antiviral Agents/pharmacology/*therapeutic use[MESH] |Humans[MESH] |Ivermectin/*pharmacology/*therapeutic use[MESH]Ivermectin as a potential drug for treatment of COVID-19: an in-sync r(epmc).pdf DeepDyve Pubget Overpricing