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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Infection 2021 ; 49 (3): 401-410 Nephropedia Template TP
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Remdesivir in Coronavirus Disease 2019 (COVID-19) treatment: a review of evidence #MMPMID33389708
Lin HXJ; Cho S; Meyyur Aravamudan V; Sanda HY; Palraj R; Molton JS; Venkatachalam I
Infection 2021[Jun]; 49 (3): 401-410 PMID33389708show ga
COVID-19 is an infectious disease caused by a novel beta-coronavirus, belonging to the same subgenus as the Severe Acute Respiratory Syndrome (SARS) virus. Remdesivir, an investigational broad-spectrum antiviral agent has previously demonstrated in vitro activity against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), and in vivo efficacy against other related coronaviruses in animal models. Its safety profile has been tested in a compassionate use setting for patients with COVID-19. The current therapeutic studies demonstrate clinical effectiveness of remdesivir in COVID-19 patients by shortening time to clinical recovery, and hospital stay. In this review, we critically analyze the current evidence of remdesivir against COVID-19 and dissect the aspects over its safety and efficacy. Based on existing data, remdesivir can be regarded as a potential therapeutic agent against COVID-19. Further large-scale, randomized placebo-controlled clinical trials are, however, awaited to validate these findings.