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10.1016/j.jgg.2020.10.002 http://scihub22266oqcxt.onion/10.1016/j.jgg.2020.10.002 33388272!7649052!33388272     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Genet+Genomics 2020 ; 47 (10): 610-617 Nephropedia Template TP {{tp|p=33388272|t=2020. Dynamics of severe acute respiratory syndrome coronavirus 2 genome variants in the feces during convalescence |pdf=|usr=}}{{33388272}} gab.com Text Dynamics of severe acute respiratory syndrome coronavirus 2 genome variants in the feces during convalescence JO: J Genet Genomics http://www.kidney.de/pget.php?&tw=1&pmid=33388272 #FOAvip In response to the current coronavirus disease 2019 (COVID-19) pandemic, it is crucial to understand the origin, transmission, and evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which relies on close surveillance of genomic diversity in clinical samples. Although the mutation at the population level had been extensively investigated, how the mutations evolve at the individual level is largely unknown. Eighteen time-series fecal samples were collected from nine patients with COVID-19 during the convalescent phase. The nucleic acids of SARS-CoV-2 were enriched by the hybrid capture method. First, we demonstrated the outstanding performance of the hybrid capture method in detecting intra-host variants. We identified 229 intra-host variants at 182 sites in 18 fecal samples. Among them, nineteen variants presented frequency changes > 0.3 within 1-5 days, reflecting highly dynamic intra-host viral populations. Moreover, the evolution of the viral genome demonstrated that the virus was probably viable in the gastrointestinal tract during the convalescent period. Meanwhile, we also found that the same mutation showed a distinct pattern of frequency changes in different individuals, indicating a strong random drift. In summary, dramatic changes of the SARS-CoV-2 genome were detected in fecal samples during the convalescent period; whether the viral load in feces is sufficient to establish an infection warranted further investigation. Twit Text FOAVip Dynamics of severe acute respiratory syndrome coronavirus 2 genome variants in the feces during convalescence ????J Genet Genomics http://www.kidney.de/pget.php?&tw=1&pmid=33388272 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33388272 #FOAvip English Wikipedia <ref>{{Cite pmid|33388272}}</ref> Dynamics of severe acute respiratory syndrome coronavirus 2 genome variants in the feces during convalescence #MMPMID33388272 Xu Y; Kang L; Shen Z; Li X; Wu W; Ma W; Fang C; Yang F; Jiang X; Gong S; Zhang L; Li M J Genet Genomics 2020[Oct]; 47 (10): 610-617 PMID33388272show ga In response to the current coronavirus disease 2019 (COVID-19) pandemic, it is crucial to understand the origin, transmission, and evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which relies on close surveillance of genomic diversity in clinical samples. Although the mutation at the population level had been extensively investigated, how the mutations evolve at the individual level is largely unknown. Eighteen time-series fecal samples were collected from nine patients with COVID-19 during the convalescent phase. The nucleic acids of SARS-CoV-2 were enriched by the hybrid capture method. First, we demonstrated the outstanding performance of the hybrid capture method in detecting intra-host variants. We identified 229 intra-host variants at 182 sites in 18 fecal samples. Among them, nineteen variants presented frequency changes > 0.3 within 1-5 days, reflecting highly dynamic intra-host viral populations. Moreover, the evolution of the viral genome demonstrated that the virus was probably viable in the gastrointestinal tract during the convalescent period. Meanwhile, we also found that the same mutation showed a distinct pattern of frequency changes in different individuals, indicating a strong random drift. In summary, dramatic changes of the SARS-CoV-2 genome were detected in fecal samples during the convalescent period; whether the viral load in feces is sufficient to establish an infection warranted further investigation. |COVID-19/epidemiology/*prevention & control/virology[MESH] |Convalescence[MESH] |Feces/*virology[MESH] |Gene Expression Profiling/methods[MESH] |Genome, Viral/*genetics[MESH] |Genomics/methods[MESH] |Haplotypes[MESH] |High-Throughput Nucleotide Sequencing/methods[MESH] |Humans[MESH] |Mutation[MESH] |Pandemics[MESH] |Polymorphism, Single Nucleotide[MESH] |SARS-CoV-2/*genetics/physiology[MESH]Dynamics of severe acute respiratory syndrome coronavirus 2 genome var(epmc).pdf DeepDyve Pubget Overpricing