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10.31083/j.rcm.2020.04.264 http://scihub22266oqcxt.onion/10.31083/j.rcm.2020.04.264 33387997!ä!33387997 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Rev+Cardiovasc+Med 2020 ; 21 (4): 517-530 Nephropedia Template TP {{tp|p=33387997|t=2020. Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19) |pdf=|usr=}}{{33387997}} gab.com Text Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19) JO: Rev Cardiovasc Med http://www.kidney.de/pget.php?&tw=1&pmid=33387997 #FOAvip The SARS-CoV-2 virus spreading across the world has led to surges of COVID-19 illness, hospitalizations, and death. The complex and multifaceted pathophysiology of life-threatening COVID-19 illness including viral mediated organ damage, cytokine storm, and thrombosis warrants early interventions to address all components of the devastating illness. In countries where therapeutic nihilism is prevalent, patients endure escalating symptoms and without early treatment can succumb to delayed in-hospital care and death. Prompt early initiation of sequenced multidrug therapy (SMDT) is a widely and currently available solution to stem the tide of hospitalizations and death. A multipronged therapeutic approach includes 1) adjuvant nutraceuticals, 2) combination intracellular anti-infective therapy, 3) inhaled/oral corticosteroids, 4) antiplatelet agents/anticoagulants, 5) supportive care including supplemental oxygen, monitoring, and telemedicine. Randomized trials of individual, novel oral therapies have not delivered tools for physicians to combat the pandemic in practice. No single therapeutic option thus far has been entirely effective and therefore a combination is required at this time. An urgent immediate pivot from single drug to SMDT regimens should be employed as a critical strategy to deal with the large numbers of acute COVID-19 patients with the aim of reducing the intensity and duration of symptoms and avoiding hospitalization and death. Twit Text FOAVip Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19) ????Rev Cardiovasc Med http://www.kidney.de/pget.php?&tw=1&pmid=33387997 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33387997 #FOAvip English Wikipedia <ref>{{Cite pmid|33387997}}</ref> Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19) #MMPMID33387997 McCullough PA; Alexander PE; Armstrong R; Arvinte C; Bain AF; Bartlett RP; Berkowitz RL; Berry AC; Borody TJ; Brewer JH; Brufsky AM; Clarke T; Derwand R; Eck A; Eck J; Eisner RA; Fareed GC; Farella A; Fonseca SNS; Geyer CE Jr; Gonnering RS; Graves KE; Gross KBV; Hazan S; Held KS; Hight HT; Immanuel S; Jacobs MM; Ladapo JA; Lee LH; Littell J; Lozano I; Mangat HS; Marble B; McKinnon JE; Merritt LD; Orient JM; Oskoui R; Pompan DC; Procter BC; Prodromos C; Rajter JC; Rajter JJ; Ram CVS; Rios SS; Risch HA; Robb MJA; Rutherford M; Scholz M; Singleton MM; Tumlin JA; Tyson BM; Urso RG; Victory K; Vliet EL; Wax CM; Wolkoff AG; Wooll V; Zelenko V Rev Cardiovasc Med 2020[Dec]; 21 (4): 517-530 PMID33387997show ga The SARS-CoV-2 virus spreading across the world has led to surges of COVID-19 illness, hospitalizations, and death. The complex and multifaceted pathophysiology of life-threatening COVID-19 illness including viral mediated organ damage, cytokine storm, and thrombosis warrants early interventions to address all components of the devastating illness. In countries where therapeutic nihilism is prevalent, patients endure escalating symptoms and without early treatment can succumb to delayed in-hospital care and death. Prompt early initiation of sequenced multidrug therapy (SMDT) is a widely and currently available solution to stem the tide of hospitalizations and death. A multipronged therapeutic approach includes 1) adjuvant nutraceuticals, 2) combination intracellular anti-infective therapy, 3) inhaled/oral corticosteroids, 4) antiplatelet agents/anticoagulants, 5) supportive care including supplemental oxygen, monitoring, and telemedicine. Randomized trials of individual, novel oral therapies have not delivered tools for physicians to combat the pandemic in practice. No single therapeutic option thus far has been entirely effective and therefore a combination is required at this time. An urgent immediate pivot from single drug to SMDT regimens should be employed as a critical strategy to deal with the large numbers of acute COVID-19 patients with the aim of reducing the intensity and duration of symptoms and avoiding hospitalization and death. |*COVID-19 Drug Treatment[MESH] |*Pandemics[MESH] |*SARS-CoV-2[MESH] |COVID-19/epidemiology[MESH] |Drug Therapy, Combination[MESH] |Humans[MESH] |Leprostatic Agents/*therapeutic use[MESH]Multifaceted highly targeted sequential multidrug treatment of early a(epmc).pdf DeepDyve Pubget Overpricing