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10.1016/j.virol.2020.12.010 http://scihub22266oqcxt.onion/10.1016/j.virol.2020.12.010 33387787!7833279!33387787     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Virology 2021 ; 554 (ä): 75-82 Nephropedia Template TP {{tp|p=33387787|t=2021. Programmed -1 Ribosomal Frameshifting in coronaviruses: A therapeutic target |pdf=|usr=}}{{33387787}} gab.com Text Programmed -1 Ribosomal Frameshifting in coronaviruses: A therapeutic target JO: Virology http://www.kidney.de/pget.php?&tw=1&pmid=33387787 #FOAvip Human population growth, climate change, and globalization are accelerating the emergence of novel pathogenic viruses. In the past two decades alone, three such members of the coronavirus family have posed serious threats, spurring intense efforts to understand their biology as a way to identify targetable vulnerabilities. Coronaviruses use a programmed -1 ribosomal frameshift (-1 PRF) mechanism to direct synthesis of their replicase proteins. This is a critical switch in their replication program that can be therapeutically targeted. Here, we discuss how nearly half a century of research into -1 PRF have provided insight into the virological importance of -1 PRF, the molecular mechanisms that drive it, and approaches that can be used to manipulate it towards therapeutic outcomes with particular emphasis on SARS-CoV-2. Twit Text FOAVip Programmed -1 Ribosomal Frameshifting in coronaviruses: A therapeutic target ????Virology http://www.kidney.de/pget.php?&tw=1&pmid=33387787 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33387787 #FOAvip English Wikipedia <ref>{{Cite pmid|33387787}}</ref> Programmed -1 Ribosomal Frameshifting in coronaviruses: A therapeutic target #MMPMID33387787 Kelly JA; Woodside MT; Dinman JD Virology 2021[Feb]; 554 (ä): 75-82 PMID33387787show ga Human population growth, climate change, and globalization are accelerating the emergence of novel pathogenic viruses. In the past two decades alone, three such members of the coronavirus family have posed serious threats, spurring intense efforts to understand their biology as a way to identify targetable vulnerabilities. Coronaviruses use a programmed -1 ribosomal frameshift (-1 PRF) mechanism to direct synthesis of their replicase proteins. This is a critical switch in their replication program that can be therapeutically targeted. Here, we discuss how nearly half a century of research into -1 PRF have provided insight into the virological importance of -1 PRF, the molecular mechanisms that drive it, and approaches that can be used to manipulate it towards therapeutic outcomes with particular emphasis on SARS-CoV-2. |Antiviral Agents/chemistry/*pharmacology/therapeutic use[MESH] |Coronavirus Infections/drug therapy[MESH] |Coronavirus/*drug effects/*genetics/growth & development/physiology[MESH] |Frameshifting, Ribosomal/*drug effects/genetics/physiology[MESH] |Gene Expression Regulation, Viral[MESH] |Humans[MESH] |Mutation[MESH] |Nucleic Acid Conformation[MESH] |RNA, Viral/chemistry/genetics/metabolism[MESH] |SARS-CoV-2/drug effects/genetics/growth & development/physiology[MESH]Programmed -1 Ribosomal Frameshifting in coronaviruses: A therapeutic (epmc).pdf DeepDyve Pubget Overpricing