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10.1002/jmv.26769

http://scihub22266oqcxt.onion/10.1002/jmv.26769
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33386773!ä!33386773

suck abstract from ncbi


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pmid33386773      J+Med+Virol 2021 ; 93 (4): 1923-1925
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  • SARS-CoV-2 nucleocapsid protein intranasal inoculation induces local and systemic T cell responses in mice #MMPMID33386773
  • He J; Huang JR; Zhang YL; Zhang J
  • J Med Virol 2021[Apr]; 93 (4): 1923-1925 PMID33386773show ga
  • SARS-CoV-2 nucleocapsid (N) protein has been proposed as a good vaccine target. N-specific T cells were observed in SARS-CoV-2 N immunized mice and COVID-19 convalescents. It is of importance to identify the T cell responses triggered by SARS-CoV-2 N protein. Intradermal immunization with SARS-CoV N protein was demonstrated to elicit non-protective T cell responses which may be avoided by intranasal vaccination. Therefore, we conducted intranasal vaccination of BALB/c mice with recombinant adenovirus type-5 expressing SARS-CoV-2 N protein. Such procedure induced CD8 T cell responses in the lung. Meanwhile CD4 T cell responses were observed in the spleen, which was associated with robust antibody production. Our study further supports the notion that SARS-CoV-2 N protein can work as a target for vaccine development.
  • |Administration, Intranasal[MESH]
  • |Animals[MESH]
  • |Antibodies, Viral/*immunology[MESH]
  • |COVID-19/*prevention & control[MESH]
  • |Coronavirus Nucleocapsid Proteins/administration & dosage/*immunology[MESH]
  • |Mice[MESH]
  • |Mice, Inbred BALB C[MESH]
  • |Phosphoproteins/administration & dosage/immunology[MESH]
  • |SARS-CoV-2/immunology[MESH]
  • |T-Lymphocytes/*immunology[MESH]
  • |Vaccination[MESH]


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