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10.1111/cbdd.13822

http://scihub22266oqcxt.onion/10.1111/cbdd.13822
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33386649!ä!33386649

suck abstract from ncbi


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pmid33386649      Chem+Biol+Drug+Des 2021 ; 97 (4): 978-983
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  • Novel quantitative structure-activity relationship model to predict activities of natural products against COVID-19 #MMPMID33386649
  • Si Y; Xu X; Hu Y; Si H; Zhai H
  • Chem Biol Drug Des 2021[Apr]; 97 (4): 978-983 PMID33386649show ga
  • Currently, COVID-19 is spreading in a large scale while no efficient vaccine has been produced. A high-effective drug for COVID-19 is very necessary now. We established a satisfied quantitative structure-activity relationship model by gene expression programming to predict the IC50 value of natural compounds. A total of 27 natural products were optimized by heuristic method in CODESSA program to build a liner model. Based on it, only two descriptors were selected and utilized to build a nonlinear model in gene expression programming. The square of correlation coefficient and s2 of heuristic method were 0.80 and 0.10, respectively. In gene expression programming, the square of correlation coefficient and mean square error for training set were 0.91 and 0.04. The square of correlation coefficient and mean square error for test set are 0.86 and 0.1. This nonlinear model has stronger predictive ability to develop the targeted drugs of COVID-19.
  • |*COVID-19 Drug Treatment[MESH]
  • |*Quantitative Structure-Activity Relationship[MESH]
  • |Algorithms[MESH]
  • |Biological Products/pharmacology/*therapeutic use[MESH]
  • |COVID-19/pathology/virology[MESH]
  • |Heuristics[MESH]
  • |Humans[MESH]
  • |Inhibitory Concentration 50[MESH]


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