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10.1016/j.amjsurg.2020.12.024

http://scihub22266oqcxt.onion/10.1016/j.amjsurg.2020.12.024
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33384154!7836786!33384154
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suck abstract from ncbi


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pmid33384154      Am+J+Surg 2021 ; 222 (2): 431-437
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  • Periprocedural complications in patients with SARS-CoV-2 infection compared to those without infection: A nationwide propensity-matched analysis #MMPMID33384154
  • Lal BK; Prasad NK; Englum BR; Turner DJ; Siddiqui T; Carlin MM; Lake R; Sorkin JD
  • Am J Surg 2021[Aug]; 222 (2): 431-437 PMID33384154show ga
  • BACKGROUND: Reports on emergency surgery performed soon after a COVID-19 infection that are not controlled for premorbid risk-factors show increased 30-day mortality and pulmonary complications. This contributed to a virtual cessation of elective surgery during the pandemic surge. To inform evidence-based guidance on the decisions for surgery during the recovery phase of the pandemic, we compare 30-day outcomes in patients testing positive for COVID-19 before their operation, to contemporary propensity-matched COVID-19 negative patients undergoing the same procedures. METHODS: This prospective multicentre study included all patients undergoing surgery at 170 Veterans Health Administration (VA) hospitals across the United States. COVID-19 positive patients were propensity matched to COVID-19 negative patients on demographic and procedural factors. We compared 30-day outcomes between COVID-19 positive and negative patients, and the effect of time from testing positive to the date of procedure (30 days) on outcomes. RESULTS: Between March 1 and August 15, 2020, 449 COVID-19 positive and 51,238 negative patients met inclusion criteria. Propensity matching yielded 432 COVID-19 positive and 1256 negative patients among whom half underwent elective surgery. Infected patients had longer hospital stays (median seven days), higher rates of pneumonia (20.6%), ventilator requirement (7.6%), acute respiratory distress syndrome (ARDS, 17.1%), septic shock (13.7%), and ischemic stroke (5.8%), while mortality, reoperations and readmissions were not significantly different. Higher odds for ventilation and stroke persisted even when surgery was delayed 11-30 days, and for pneumonia, ARDS, and septic shock >30 days after a positive test. DISCUSSION: 30-day pulmonary, septic, and ischaemic complications are increased in COVID-19 positive, compared to propensity score matched negative patients. Odds for several complications persist despite a delay beyond ten days after testing positive. Individualized risk-stratification by pulmonary and atherosclerotic comorbidities should be considered when making decisions for delaying surgery in infected patients.
  • |*Practice Guidelines as Topic[MESH]
  • |Aged[MESH]
  • |COVID-19 Testing/statistics & numerical data[MESH]
  • |COVID-19/*complications/diagnosis/virology[MESH]
  • |Clinical Decision-Making/methods[MESH]
  • |Elective Surgical Procedures/*adverse effects/standards/statistics & numerical data[MESH]
  • |Evidence-Based Medicine/standards/statistics & numerical data[MESH]
  • |Female[MESH]
  • |Follow-Up Studies[MESH]
  • |Hospital Mortality[MESH]
  • |Hospitals, Veterans/statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Length of Stay/statistics & numerical data[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Postoperative Complications/*epidemiology/etiology/prevention & control[MESH]
  • |Propensity Score[MESH]
  • |Prospective Studies[MESH]
  • |Risk Assessment/standards/statistics & numerical data[MESH]
  • |SARS-CoV-2/isolation & purification[MESH]
  • |Time Factors[MESH]
  • |Time-to-Treatment/*standards/statistics & numerical data[MESH]


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