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10.1016/j.jsb.2020.107690 http://scihub22266oqcxt.onion/10.1016/j.jsb.2020.107690 33383190!7769706!33383190     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Struct+Biol 2021 ; 213 (1): 107690 Nephropedia Template TP {{tp|p=33383190|t=2021. Structural insights of key enzymes into therapeutic intervention against SARS-CoV-2 |pdf=|usr=}}{{33383190}} gab.com Text Structural insights of key enzymes into therapeutic intervention against SARS-CoV-2 JO: J Struct Biol http://www.kidney.de/pget.php?&tw=1&pmid=33383190 #FOAvip COVID-19 pandemic, caused by SARS-CoV-2, has drastically affected human health all over the world. After the emergence of the pandemic the major focus of efforts to attenuate the infection has been on repurposing the already approved drugs to treat COVID-19 adopting a fast-track strategy. However, to date a specific regimen to treat COVID-19 is not available. Over the last few months a substantial amount of data about the structures of various key proteins and their recognition partners involved in the SARS-CoV-2 pathogenesis has emerged. These studies have not only provided the molecular level descriptions ofthe viral pathogenesis but also laid the foundation for rational drug design and discovery. In this review, we have recapitulated the structural details of four key viral enzymes, RNA-dependent RNA polymerase, 3-chymotrypsin like protease, papain-like protease and helicase, and two host factors including angiotensin-converting enzyme 2 and transmembrane serine protease involved in the SARS-CoV-2 pathogenesis, and described the potential hotspots present on these structures which could be explored for therapeutic intervention. We have also discussed the significance of endoplasmic reticulum alpha-glucosidases as potential targets for anti-SARS-CoV-2 drug discovery. Twit Text FOAVip Structural insights of key enzymes into therapeutic intervention against SARS-CoV-2 ????J Struct Biol http://www.kidney.de/pget.php?&tw=1&pmid=33383190 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33383190 #FOAvip English Wikipedia <ref>{{Cite pmid|33383190}}</ref> Structural insights of key enzymes into therapeutic intervention against SARS-CoV-2 #MMPMID33383190 Shahid M; Shahzad-Ul-Hussan S J Struct Biol 2021[Mar]; 213 (1): 107690 PMID33383190show ga COVID-19 pandemic, caused by SARS-CoV-2, has drastically affected human health all over the world. After the emergence of the pandemic the major focus of efforts to attenuate the infection has been on repurposing the already approved drugs to treat COVID-19 adopting a fast-track strategy. However, to date a specific regimen to treat COVID-19 is not available. Over the last few months a substantial amount of data about the structures of various key proteins and their recognition partners involved in the SARS-CoV-2 pathogenesis has emerged. These studies have not only provided the molecular level descriptions ofthe viral pathogenesis but also laid the foundation for rational drug design and discovery. In this review, we have recapitulated the structural details of four key viral enzymes, RNA-dependent RNA polymerase, 3-chymotrypsin like protease, papain-like protease and helicase, and two host factors including angiotensin-converting enzyme 2 and transmembrane serine protease involved in the SARS-CoV-2 pathogenesis, and described the potential hotspots present on these structures which could be explored for therapeutic intervention. We have also discussed the significance of endoplasmic reticulum alpha-glucosidases as potential targets for anti-SARS-CoV-2 drug discovery. |*COVID-19 Drug Treatment[MESH] |Angiotensin-Converting Enzyme 2/metabolism[MESH] |Antiviral Agents/*therapeutic use[MESH] |COVID-19/*metabolism/virology[MESH] |Coronavirus 3C Proteases/chemistry/metabolism[MESH] |Coronavirus RNA-Dependent RNA Polymerase/metabolism[MESH] |Exoribonucleases/metabolism[MESH] |Host-Pathogen Interactions/drug effects[MESH] |Humans[MESH] |Methyltransferases/metabolism[MESH] |RNA Helicases/metabolism[MESH] |SARS-CoV-2/*drug effects/*enzymology/physiology[MESH] |Serine Endopeptidases/metabolism[MESH]Structural insights of key enzymes into therapeutic intervention again(epmc).pdf DeepDyve Pubget Overpricing