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10.1016/j.ygeno.2020.12.036

http://scihub22266oqcxt.onion/10.1016/j.ygeno.2020.12.036
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33383142!7833309!33383142
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suck abstract from ncbi


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pmid33383142      Genomics 2021 ; 113 (2): 456-462
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  • Comprehensive analysis of TCR repertoire in COVID-19 using single cell sequencing #MMPMID33383142
  • Wang P; Jin X; Zhou W; Luo M; Xu Z; Xu C; Li Y; Ma K; Cao H; Huang Y; Xue G; Jin S; Nie H; Jiang Q
  • Genomics 2021[Mar]; 113 (2): 456-462 PMID33383142show ga
  • T-cell receptor (TCR) is crucial in T cell-mediated virus clearance. To date, TCR bias has been observed in various diseases. However, studies on the TCR repertoire of COVID-19 patients are lacking. Here, we used single-cell V(D)J sequencing to conduct comparative analyses of TCR repertoire between 12 COVID-19 patients and 6 healthy controls, as well as other virus-infected samples. We observed distinct T cell clonal expansion in COVID-19. Further analysis of VJ gene combination revealed 6 VJ pairs significantly increased, while 139 pairs significantly decreased in COVID-19 patients. When considering the VJ combination of alpha and beta chains at the same time, the combination with the highest frequency on COVID-19 was TRAV12-2-J27-TRBV7-9-J2-3. Besides, preferential usage of V and J gene segments was also observed in samples infected by different viruses. Our study provides novel insights on TCR in COVID-19, which contribute to our understanding of the immune response induced by SARS-CoV-2.
  • |*High-Throughput Nucleotide Sequencing[MESH]
  • |*SARS-CoV-2[MESH]
  • |*Single-Cell Analysis[MESH]
  • |COVID-19/*genetics/immunology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Receptors, Antigen, T-Cell/*genetics[MESH]


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