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10.1016/j.lfs.2020.118959 http://scihub22266oqcxt.onion/10.1016/j.lfs.2020.118959 33383045!ä!33383045 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Life+Sci 2021 ; 268 (ä): 118959 Nephropedia Template TP {{tp|p=33383045|t=2021. A bird eye view on cystic fibrosis: An underestimated multifaceted chronic disorder |pdf=|usr=}}{{33383045}} gab.com Text A bird eye view on cystic fibrosis: An underestimated multifaceted chronic disorder JO: Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=33383045 #FOAvip Cystic fibrosis (CF) is an autosomal recessive disease which involves the mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. CF involves in the inflammatory processes and is considered as a multisystem disorder that is not confined to lungs, but it also affects other vital organs that leads to numerous co-morbidities. The respiratory disorder in the CF results in mortality and morbidity which is characterized by series of serious events involving mucus hypersecretion, microbial infections, airways obstruction, inflammation, destruction of epithelium, tissue remodeling and terminal lung diseases. Mucins are the high molecular weight glycoproteins important for the viscoelastic properties of the mucus, play a significant role in the disease mechanisms. Determining the functional association between the CFTR and mucins might help to identify the putative target for specific therapeutic approach. In fact, furin enzyme which helps in the entry of novel COVID-19 virus into the cell, is upregulated in CF and this can also serve as a potential target for CF treatment. Moreover, the use of nano-formulations for CF treatment is an area of research being widely studied as they have also demonstrated promising outcomes. The in-depth knowledge of non-coding RNAs like miRNAs and lncRNAs and their functional association with CFTR gene expression and mutation can provide a different range of opportunity to identify the promising therapeutic approaches for CF. Twit Text FOAVip A bird eye view on cystic fibrosis: An underestimated multifaceted chronic disorder ????Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=33383045 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33383045 #FOAvip English Wikipedia <ref>{{Cite pmid|33383045}}</ref> A bird eye view on cystic fibrosis: An underestimated multifaceted chronic disorder #MMPMID33383045 Kotnala S; Dhasmana A; Kashyap VK; Chauhan SC; Yallapu MM; Jaggi M Life Sci 2021[Mar]; 268 (ä): 118959 PMID33383045show ga Cystic fibrosis (CF) is an autosomal recessive disease which involves the mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. CF involves in the inflammatory processes and is considered as a multisystem disorder that is not confined to lungs, but it also affects other vital organs that leads to numerous co-morbidities. The respiratory disorder in the CF results in mortality and morbidity which is characterized by series of serious events involving mucus hypersecretion, microbial infections, airways obstruction, inflammation, destruction of epithelium, tissue remodeling and terminal lung diseases. Mucins are the high molecular weight glycoproteins important for the viscoelastic properties of the mucus, play a significant role in the disease mechanisms. Determining the functional association between the CFTR and mucins might help to identify the putative target for specific therapeutic approach. In fact, furin enzyme which helps in the entry of novel COVID-19 virus into the cell, is upregulated in CF and this can also serve as a potential target for CF treatment. Moreover, the use of nano-formulations for CF treatment is an area of research being widely studied as they have also demonstrated promising outcomes. The in-depth knowledge of non-coding RNAs like miRNAs and lncRNAs and their functional association with CFTR gene expression and mutation can provide a different range of opportunity to identify the promising therapeutic approaches for CF. |Animals[MESH] |COVID-19/*virology[MESH] |Cystic Fibrosis Transmembrane Conductance Regulator/*genetics[MESH] |Cystic Fibrosis/genetics/*physiopathology/therapy[MESH] |Gene Expression Regulation[MESH] |Humans[MESH] |MicroRNAs/genetics[MESH] |Mucins/metabolism[MESH] |Mutation[MESH] |RNA, Long Noncoding/genetics[MESH]A bird eye view on cystic fibrosis: An underestimated multifaceted chr(epmc).pdf DeepDyve Pubget Overpricing