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10.1016/j.immuni.2020.12.011 http://scihub22266oqcxt.onion/10.1016/j.immuni.2020.12.011 33382973!7831653!33382973     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2021 ; 54 (1): 164-175.e6 Nephropedia Template TP {{tp|p=33382973|t=2021. Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid |pdf=|usr=}}{{33382973}} gab.com Text Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=33382973 #FOAvip Patients suffering from Coronavirus disease 2019 (COVID-19) can develop neurological sequelae, such as headache and neuroinflammatory or cerebrovascular disease. These conditions-termed here as Neuro-COVID-are more frequent in patients with severe COVID-19. To understand the etiology of these neurological sequelae, we utilized single-cell sequencing and examined the immune cell profiles from the cerebrospinal fluid (CSF) of Neuro-COVID patients compared with patients with non-inflammatory and autoimmune neurological diseases or with viral encephalitis. The CSF of Neuro-COVID patients exhibited an expansion of dedifferentiated monocytes and of exhausted CD4(+) T cells. Neuro-COVID CSF leukocytes featured an enriched interferon signature; however, this was less pronounced than in viral encephalitis. Repertoire analysis revealed broad clonal T cell expansion and curtailed interferon response in severe compared with mild Neuro-COVID patients. Collectively, our findings document the CSF immune compartment in Neuro-COVID patients and suggest compromised antiviral responses in this setting. Twit Text FOAVip Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=33382973 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33382973 #FOAvip English Wikipedia <ref>{{Cite pmid|33382973}}</ref> Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid #MMPMID33382973 Heming M; Li X; Rauber S; Mausberg AK; Borsch AL; Hartlehnert M; Singhal A; Lu IN; Fleischer M; Szepanowski F; Witzke O; Brenner T; Dittmer U; Yosef N; Kleinschnitz C; Wiendl H; Stettner M; Meyer Zu Horste G Immunity 2021[Jan]; 54 (1): 164-175.e6 PMID33382973show ga Patients suffering from Coronavirus disease 2019 (COVID-19) can develop neurological sequelae, such as headache and neuroinflammatory or cerebrovascular disease. These conditions-termed here as Neuro-COVID-are more frequent in patients with severe COVID-19. To understand the etiology of these neurological sequelae, we utilized single-cell sequencing and examined the immune cell profiles from the cerebrospinal fluid (CSF) of Neuro-COVID patients compared with patients with non-inflammatory and autoimmune neurological diseases or with viral encephalitis. The CSF of Neuro-COVID patients exhibited an expansion of dedifferentiated monocytes and of exhausted CD4(+) T cells. Neuro-COVID CSF leukocytes featured an enriched interferon signature; however, this was less pronounced than in viral encephalitis. Repertoire analysis revealed broad clonal T cell expansion and curtailed interferon response in severe compared with mild Neuro-COVID patients. Collectively, our findings document the CSF immune compartment in Neuro-COVID patients and suggest compromised antiviral responses in this setting. |COVID-19/cerebrospinal fluid/complications/*immunology/pathology[MESH] |Cell Differentiation[MESH] |Cerebrospinal Fluid/immunology[MESH] |Encephalitis, Viral/cerebrospinal fluid/immunology[MESH] |Gene Expression Profiling[MESH] |Humans[MESH] |Interferons/genetics/immunology[MESH] |Leukocytes/immunology[MESH] |Lymphocyte Activation[MESH] |Monocytes/*immunology[MESH] |Nervous System Diseases/cerebrospinal fluid/etiology/*immunology/pathology[MESH] |Receptors, Antigen, T-Cell/genetics/metabolism[MESH] |SARS-CoV-2/immunology[MESH] |Single-Cell Analysis[MESH]Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and (epmc).pdf DeepDyve Pubget Overpricing