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10.1016/j.cell.2020.12.006 http://scihub22266oqcxt.onion/10.1016/j.cell.2020.12.006 33382968!7796900!33382968     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2021 ; 184 (1): 120-132.e14 Nephropedia Template TP {{tp|p=33382968|t=2021. Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks |pdf=|usr=}}{{33382968}} gab.com Text Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=33382968 #FOAvip The coronavirus disease 2019 (COVID-19) pandemic has claimed the lives of over one million people worldwide. The causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a member of the Coronaviridae family of viruses that can cause respiratory infections of varying severity. The cellular host factors and pathways co-opted during SARS-CoV-2 and related coronavirus life cycles remain ill defined. To address this gap, we performed genome-scale CRISPR knockout screens during infection by SARS-CoV-2 and three seasonal coronaviruses (HCoV-OC43, HCoV-NL63, and HCoV-229E). These screens uncovered host factors and pathways with pan-coronavirus and virus-specific functional roles, including major dependency on glycosaminoglycan biosynthesis, sterol regulatory element-binding protein (SREBP) signaling, bone morphogenetic protein (BMP) signaling, and glycosylphosphatidylinositol biosynthesis, as well as a requirement for several poorly characterized proteins. We identified an absolute requirement for the VMP1, TMEM41, and TMEM64 (VTT) domain-containing protein transmembrane protein 41B (TMEM41B) for infection by SARS-CoV-2 and three seasonal coronaviruses. This human coronavirus host factor compendium represents a rich resource to develop new therapeutic strategies for acute COVID-19 and potential future coronavirus pandemics. Twit Text FOAVip Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=33382968 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33382968 #FOAvip English Wikipedia <ref>{{Cite pmid|33382968}}</ref> Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks #MMPMID33382968 Schneider WM; Luna JM; Hoffmann HH; Sanchez-Rivera FJ; Leal AA; Ashbrook AW; Le Pen J; Ricardo-Lax I; Michailidis E; Peace A; Stenzel AF; Lowe SW; MacDonald MR; Rice CM; Poirier JT Cell 2021[Jan]; 184 (1): 120-132.e14 PMID33382968show ga The coronavirus disease 2019 (COVID-19) pandemic has claimed the lives of over one million people worldwide. The causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a member of the Coronaviridae family of viruses that can cause respiratory infections of varying severity. The cellular host factors and pathways co-opted during SARS-CoV-2 and related coronavirus life cycles remain ill defined. To address this gap, we performed genome-scale CRISPR knockout screens during infection by SARS-CoV-2 and three seasonal coronaviruses (HCoV-OC43, HCoV-NL63, and HCoV-229E). These screens uncovered host factors and pathways with pan-coronavirus and virus-specific functional roles, including major dependency on glycosaminoglycan biosynthesis, sterol regulatory element-binding protein (SREBP) signaling, bone morphogenetic protein (BMP) signaling, and glycosylphosphatidylinositol biosynthesis, as well as a requirement for several poorly characterized proteins. We identified an absolute requirement for the VMP1, TMEM41, and TMEM64 (VTT) domain-containing protein transmembrane protein 41B (TMEM41B) for infection by SARS-CoV-2 and three seasonal coronaviruses. This human coronavirus host factor compendium represents a rich resource to develop new therapeutic strategies for acute COVID-19 and potential future coronavirus pandemics. |*Genome-Wide Association Study[MESH] |A549 Cells[MESH] |Cell Line[MESH] |Clustered Regularly Interspaced Short Palindromic Repeats[MESH] |Coronavirus 229E, Human/physiology[MESH] |Coronavirus Infections/*genetics/virology[MESH] |Coronavirus NL63, Human/physiology[MESH] |Coronavirus OC43, Human/physiology[MESH] |Gene Knockout Techniques[MESH] |HEK293 Cells[MESH] |Host-Pathogen Interactions/drug effects[MESH] |Humans[MESH] |Membrane Proteins/metabolism[MESH] |Metabolic Networks and Pathways/drug effects[MESH] |Protein Interaction Mapping[MESH]Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Fac(epmc).pdf DeepDyve Pubget Overpricing