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10.1002/rmv.2204 http://scihub22266oqcxt.onion/10.1002/rmv.2204 33382930!7883262!33382930     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Rev+Med+Virol 2021 ; 31 (5): 1-14 Nephropedia Template TP {{tp|p=33382930|t=2021. Mega doses of retinol: A possible immunomodulation in Covid-19 illness in resource-limited settings |pdf=|usr=}}{{33382930}} gab.com Text Mega doses of retinol: A possible immunomodulation in Covid-19 illness in resource-limited settings JO: Rev Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=33382930 #FOAvip Of all the nutrients, vitamin A has been the most extensively evaluated for its impact on immunity. There are three main forms of vitamin A, retinol, retinal and retinoic acid (RA) with the latter being most biologically active and all-trans-RA (ATRA) its main derivative. Vitamin A is a key regulator of the functions of various innate and adaptive immune cells and promotes immune-homeostasis. Importantly, it augments the interferon-based innate immune response to RNA viruses decreasing RNA virus replication. Several clinical trials report decreased mortality in measles and Ebola with vitamin A supplementation.During the Covid-19 pandemic interventions such as convalescent plasma, antivirals, monoclonal antibodies and immunomodulator drugs have been tried but most of them are difficult to implement in resource-limited settings. The current review explores the possibility of mega dose vitamin A as an affordable adjunct therapy for Covid-19 illness with minimal reversible side effects. Insight is provided into the effect of vitamin A on ACE-2 expression in the respiratory tract and its association with the prognosis of Covid-19 patients. Vitamin A supplementation may aid the generation of protective immune response to Covid-19 vaccines. An overview of the dosage and safety profile of vitamin A is presented along with recommended doses for prophylactic/therapeutic use in randomised controlled trials in Covid-19 patients. Twit Text FOAVip Mega doses of retinol: A possible immunomodulation in Covid-19 illness in resource-limited settings ????Rev Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=33382930 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33382930 #FOAvip English Wikipedia <ref>{{Cite pmid|33382930}}</ref> Mega doses of retinol: A possible immunomodulation in Covid-19 illness in resource-limited settings #MMPMID33382930 Midha IK; Kumar N; Kumar A; Madan T Rev Med Virol 2021[Sep]; 31 (5): 1-14 PMID33382930show ga Of all the nutrients, vitamin A has been the most extensively evaluated for its impact on immunity. There are three main forms of vitamin A, retinol, retinal and retinoic acid (RA) with the latter being most biologically active and all-trans-RA (ATRA) its main derivative. Vitamin A is a key regulator of the functions of various innate and adaptive immune cells and promotes immune-homeostasis. Importantly, it augments the interferon-based innate immune response to RNA viruses decreasing RNA virus replication. Several clinical trials report decreased mortality in measles and Ebola with vitamin A supplementation.During the Covid-19 pandemic interventions such as convalescent plasma, antivirals, monoclonal antibodies and immunomodulator drugs have been tried but most of them are difficult to implement in resource-limited settings. The current review explores the possibility of mega dose vitamin A as an affordable adjunct therapy for Covid-19 illness with minimal reversible side effects. Insight is provided into the effect of vitamin A on ACE-2 expression in the respiratory tract and its association with the prognosis of Covid-19 patients. Vitamin A supplementation may aid the generation of protective immune response to Covid-19 vaccines. An overview of the dosage and safety profile of vitamin A is presented along with recommended doses for prophylactic/therapeutic use in randomised controlled trials in Covid-19 patients. |Animals[MESH] |COVID-19/*immunology/*prevention & control/virology[MESH] |Humans[MESH] |Immunity/drug effects[MESH] |Immunomodulation/drug effects[MESH] |SARS-CoV-2/genetics/physiology[MESH]Mega doses of retinol: A possible immunomodulation in Covid-19 illness(epmc).pdf DeepDyve Pubget Overpricing