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10.1371/journal.pone.0244628 http://scihub22266oqcxt.onion/10.1371/journal.pone.0244628 33382773!7774924!33382773     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2020 ; 15 (12): e0244628 Nephropedia Template TP {{tp|p=33382773|t=2020. Interleukine-6 in critically ill COVID-19 patients: A retrospective analysis |pdf=|usr=}}{{33382773}} gab.com Text Interleukine-6 in critically ill COVID-19 patients: A retrospective analysis JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=33382773 #FOAvip INTRODUCTION: Coronavirus disease 2019 (COVID-19) appeared in China in December 2019 and has spread around the world. High Interleukin-6 (IL-6) levels in COVID-19 patients suggest that a cytokine storm may play a major role in the pathophysiology and are considered as a relevant parameter in predicting most severe course of disease. The aim of this study was to assess repeated IL-6 levels in critically ill COVID-19 patients admitted to our Intensive Care Unit (ICU) and to evaluate their relationship with patient's severity and outcome. METHODS: We conducted a retrospective study on patients admitted to the ICU with a diagnosis of COVID-19 between March 10 (i.e. the date of the first admitted patients) and April 30, 2020. Demographic, clinical and laboratory data were collected at admission. On the day of IL-6 blood concentration measurement, we also collected results of D-Dimers, C-Reactive Protein, white blood cells and lymphocytes count, lactate dehydrogenase (LDH) and ferritin as well as microbiological samples, whenever present. RESULTS: Of a total of 65 patients with COVID-19 admitted to our ICU we included 41 patients with repeated measure of IL-6. There was a significant difference in IL-6 levels between survivors and non-survivors over time (p = 0.001); moreover, non survivors had a significantly higher IL-6 maximal value when compared to survivors (720 [349-2116] vs. 336 [195-646] pg/mL, p = 0.01). The IL-6 maximal value had a significant predictive value of ICU mortality (AUROC 0.73 [95% CI 0.57-0.89]; p = 0.01). CONCLUSIONS: Repeated measurements of IL-6 can help clinicians in identifying critically ill COVID-19 patients with the highest risk of poor prognosis. Twit Text FOAVip Interleukine-6 in critically ill COVID-19 patients: A retrospective analysis ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=33382773 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33382773 #FOAvip English Wikipedia <ref>{{Cite pmid|33382773}}</ref> Interleukine-6 in critically ill COVID-19 patients: A retrospective analysis #MMPMID33382773 Gorham J; Moreau A; Corazza F; Peluso L; Ponthieux F; Talamonti M; Izzi A; Nagant C; Ndieugnou Djangang N; Garufi A; Creteur J; Taccone FS PLoS One 2020[]; 15 (12): e0244628 PMID33382773show ga INTRODUCTION: Coronavirus disease 2019 (COVID-19) appeared in China in December 2019 and has spread around the world. High Interleukin-6 (IL-6) levels in COVID-19 patients suggest that a cytokine storm may play a major role in the pathophysiology and are considered as a relevant parameter in predicting most severe course of disease. The aim of this study was to assess repeated IL-6 levels in critically ill COVID-19 patients admitted to our Intensive Care Unit (ICU) and to evaluate their relationship with patient's severity and outcome. METHODS: We conducted a retrospective study on patients admitted to the ICU with a diagnosis of COVID-19 between March 10 (i.e. the date of the first admitted patients) and April 30, 2020. Demographic, clinical and laboratory data were collected at admission. On the day of IL-6 blood concentration measurement, we also collected results of D-Dimers, C-Reactive Protein, white blood cells and lymphocytes count, lactate dehydrogenase (LDH) and ferritin as well as microbiological samples, whenever present. RESULTS: Of a total of 65 patients with COVID-19 admitted to our ICU we included 41 patients with repeated measure of IL-6. There was a significant difference in IL-6 levels between survivors and non-survivors over time (p = 0.001); moreover, non survivors had a significantly higher IL-6 maximal value when compared to survivors (720 [349-2116] vs. 336 [195-646] pg/mL, p = 0.01). The IL-6 maximal value had a significant predictive value of ICU mortality (AUROC 0.73 [95% CI 0.57-0.89]; p = 0.01). CONCLUSIONS: Repeated measurements of IL-6 can help clinicians in identifying critically ill COVID-19 patients with the highest risk of poor prognosis. |*SARS-CoV-2[MESH] |COVID-19/*blood/*mortality[MESH] |Critical Illness[MESH] |Cytokine Release Syndrome/*blood/*mortality[MESH] |Disease-Free Survival[MESH] |Female[MESH] |Humans[MESH] |Interleukin-6/*blood[MESH] |Male[MESH] |Middle Aged[MESH] |Retrospective Studies[MESH] |Severity of Illness Index[MESH]Interleukine-6 in critically ill COVID-19 patients: A retrospective an(epmc).pdf DeepDyve Pubget Overpricing