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Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Expert+Rev+Respir+Med 2021 ; 15 (4): 553-559 Nephropedia Template TP
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Changes of peripheral lymphocyte subset in patients with SARS-CoV-2 infection during the whole course of disease #MMPMID33382362
Yu X; Yang R
Expert Rev Respir Med 2021[Apr]; 15 (4): 553-559 PMID33382362show ga
Background: Little is known about changes in lymphocyte subsets after SARS-CoV-2 infection.Methods: Clinical data of 580 COVID-19 patients hospitalized in Zhongnan Hospital of Wuhan University from 20 December 2019, to 8 March 2020, were retrospectively analyzed. The relation of lymphocyte subsets and severity or prognosis of disease were analyzed.Results: At 2-3 weeks after the onset of symptoms, lymphocyte subsets decreased to the lowest levels. The levels of lymphocyte subsets in asymptomatic patients were close to healthy persons, except for CD8(+) T lymphocyte cells. The levels of lymphocyte subsets in patients with severe illness were lower than that in patients with mild-to-moderate illness (P < 0.01). Similarly, among patients with severe illness, lower levels of lymphocyte subsets were found in dead patients compared to survivors (P < 0.001). Moreover, by comparing the results of the same patients at different stages of the disease, we found levels of lymphocyte subsets were lower in the acute phase compared to that in convalescent-phase (P < 0.001). However, the levels of lymphocyte subsets in patients who had SARS-CoV-2 viral load >5000 copies/ml and 500-5000 copies/ml were at similar levels.Conclusions: Lymphocyte subsets are a good biomarker to assess the severity and prognosis of the disease at 2-3 weeks after the onset of symptoms.