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10.1016/j.biopha.2020.111072

http://scihub22266oqcxt.onion/10.1016/j.biopha.2020.111072
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suck abstract from ncbi


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pmid33378971      Biomed+Pharmacother 2021 ; 133 (ä): 111072
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  • Traditional Chinese medicine combined with pulmonary drug delivery system and idiopathic pulmonary fibrosis: Rationale and therapeutic potential #MMPMID33378971
  • Zhang Y; Lu P; Qin H; Zhang Y; Sun X; Song X; Liu J; Peng H; Liu Y; Nwafor EO; Li J; Liu Z
  • Biomed Pharmacother 2021[Jan]; 133 (ä): 111072 PMID33378971show ga
  • Idiopathic pulmonary fibrosis (IPF) is a progressive pulmonary interstitial inflammatory disease of unknown etiology, and is also a sequela in severe patients with the Coronavirus Disease 2019 (COVID-19). Nintedanib and pirfenidone are the only two known drugs which are conditionally recommended for the treatment of IPF by the FDA. However, these drugs pose some adverse side effects such as nausea and diarrhoea during clinical applications. Therefore, it is of great value and significance to identify effective and safe therapeutic drugs to solve the clinical problems associated with intake of western medicine. As a unique medical treatment, Traditional Chinese Medicine (TCM) has gradually exerted its advantages in the treatment of IPF worldwide through a multi-level and multi-target approach. Further, to overcome the current clinical problems of oral and injectable intakes of TCM, pulmonary drug delivery system (PDDS) could be designed to reduce the systemic metabolism and adverse reactions of the drug and to improve the bioavailability of drugs. Through PubMed, Google Scholar, Web of Science, and CNKI, we retrieved articles published in related fields in recent years, and this paper has summarized twenty-seven Chinese compound prescriptions, ten single TCM, and ten active ingredients for effective prevention and treatment of IPF. We also introduce three kinds of inhaling PDDS, which supports further research of TCM combined with PDDS to treat IPF.
  • |*Phytotherapy[MESH]
  • |COVID-19/*complications[MESH]
  • |Drug Compounding[MESH]
  • |Drugs, Chinese Herbal/administration & dosage/chemistry/*therapeutic use[MESH]
  • |History, 15th Century[MESH]
  • |History, 16th Century[MESH]
  • |History, 17th Century[MESH]
  • |History, 18th Century[MESH]
  • |History, 19th Century[MESH]
  • |History, 20th Century[MESH]
  • |History, Ancient[MESH]
  • |History, Medieval[MESH]
  • |Humans[MESH]
  • |Idiopathic Pulmonary Fibrosis/*drug therapy/etiology/prevention & control[MESH]
  • |Medicine, Chinese Traditional/history/*methods[MESH]
  • |Nebulizers and Vaporizers[MESH]


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