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10.1111/tid.13556

http://scihub22266oqcxt.onion/10.1111/tid.13556
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33378571!7883059!33378571
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suck abstract from ncbi


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pmid33378571      Transpl+Infect+Dis 2021 ; 23 (2): e13556
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  • A retrospective matched cohort single-center study evaluating outcomes of COVID-19 and the impact of immunomodulation on COVID-19-related cytokine release syndrome in solid organ transplant recipients #MMPMID33378571
  • Ringer M; Azmy V; Kaman K; Tang D; Cheung H; Azar MM; Price C; Malinis M
  • Transpl Infect Dis 2021[Apr]; 23 (2): e13556 PMID33378571show ga
  • This retrospective matched cohort study describes 30 solid organ transplant (SOT) patients with Coronavirus Disease 2019 (COVID-19) matched 1:2 to 60 non-SOT patients (control group) based on age, body mass index (BMI), and comorbidities (hypertension and diabetes mellitus with hemoglobin A1c > 8.0%). The SOT group had a higher proportion of cardiovascular disease (P < .05). During the index hospitalization, there were no significant differences with regard to disease severity or critical care needs (mechanical intubation, vasopressors, and renal replacement therapy). At 28 days, 4 (13%) patients died in the SOT group and 8 (13%) patients died in the control group (P = 1.0). Nineteen patients received tocilizumab in the SOT group compared to 29 patients in the control group. Among these patients, interleukin-6 (IL-6) and soluble interleukin-2 receptor (sIL2R) levels increased after tocilizumab and interleukin-10 (IL-10) levels decreased after tocilizumab. Overall, SOT patients had comparable mortality to non-SOT patients, although numerically more SOT patients received tocilizumab (63% vs 48%) and steroids (37% vs 20%). Larger, multi-center studies are needed to ascertain these findings. Lastly, the complex cytokine release syndrome in COVID-19 remains an area of intense research and the analysis of key interleukin levels (IL-6, IL-10, and sIL2R) in this study contributes to the understanding of this process.
  • |*Kidney Transplantation[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Antibodies, Monoclonal, Humanized/therapeutic use[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |COVID-19/*immunology/mortality/physiopathology[MESH]
  • |Case-Control Studies[MESH]
  • |Cohort Studies[MESH]
  • |Comorbidity[MESH]
  • |Cytokine Release Syndrome/drug therapy/*immunology/physiopathology[MESH]
  • |Female[MESH]
  • |Glucocorticoids/*therapeutic use[MESH]
  • |Graft Rejection/*prevention & control[MESH]
  • |Heart Transplantation[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Immunologic Factors/therapeutic use[MESH]
  • |Immunosuppressive Agents/*therapeutic use[MESH]
  • |Interleukin-10/immunology[MESH]
  • |Interleukin-6/immunology[MESH]
  • |Liver Transplantation[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Receptors, Interleukin-2/immunology[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]
  • |Severity of Illness Index[MESH]
  • |Treatment Outcome[MESH]


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