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10.1093/bib/bbaa383 http://scihub22266oqcxt.onion/10.1093/bib/bbaa383 33377145!7953982!33377145     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Brief+Bioinform 2021 ; 22 (2): 1006-1022 Nephropedia Template TP {{tp|p=33377145|t=2021. Evolutionary and codon usage preference insights into spike glycoprotein of SARS-CoV-2 |pdf=|usr=}}{{33377145}} gab.com Text Evolutionary and codon usage preference insights into spike glycoprotein of SARS-CoV-2 JO: Brief Bioinform http://www.kidney.de/pget.php?&tw=1&pmid=33377145 #FOAvip Interaction of SARS-CoV-2 spike glycoprotein with the ACE2 cell receptor is very crucial for virus attachment to human cells. Selected mutations in SARS-CoV-2 S-protein are reported to strengthen its binding affinity to mammalian ACE2. The N501T mutation in SARS-CoV-2-CTD furnishes better support to hotspot 353 in comparison with SARS-CoV and shows higher affinity for receptor binding. Recombination analysis exhibited higher recombination events in SARS-CoV-2 strains, irrespective of their geographical origin or hosts. Investigation further supports a common origin among SARS-CoV-2 and its predecessors, SARS-CoV and bat-SARS-like-CoV. The recombination events suggest a constant exchange of genetic material among the co-infecting viruses in possible reservoirs and human hosts before SARS-CoV-2 emerged. Furthermore, a comprehensive analysis of codon usage bias (CUB) in SARS-CoV-2 revealed significant CUB among the S-genes of different beta-coronaviruses governed majorly by natural selection and mutation pressure. Various indices of codon usage of S-genes helped in quantifying its adaptability in other animal hosts. These findings might help in identifying potential experimental animal models for investigating pathogenicity for drugs and vaccine development experiments. Twit Text FOAVip Evolutionary and codon usage preference insights into spike glycoprotein of SARS-CoV-2 ????Brief Bioinform http://www.kidney.de/pget.php?&tw=1&pmid=33377145 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33377145 #FOAvip English Wikipedia <ref>{{Cite pmid|33377145}}</ref> Evolutionary and codon usage preference insights into spike glycoprotein of SARS-CoV-2 #MMPMID33377145 Malik YS; Ansari MI; Kattoor JJ; Kaushik R; Sircar S; Subbaiyan A; Tiwari R; Dhama K; Ghosh S; Tomar S; Zhang KYJ Brief Bioinform 2021[Mar]; 22 (2): 1006-1022 PMID33377145show ga Interaction of SARS-CoV-2 spike glycoprotein with the ACE2 cell receptor is very crucial for virus attachment to human cells. Selected mutations in SARS-CoV-2 S-protein are reported to strengthen its binding affinity to mammalian ACE2. The N501T mutation in SARS-CoV-2-CTD furnishes better support to hotspot 353 in comparison with SARS-CoV and shows higher affinity for receptor binding. Recombination analysis exhibited higher recombination events in SARS-CoV-2 strains, irrespective of their geographical origin or hosts. Investigation further supports a common origin among SARS-CoV-2 and its predecessors, SARS-CoV and bat-SARS-like-CoV. The recombination events suggest a constant exchange of genetic material among the co-infecting viruses in possible reservoirs and human hosts before SARS-CoV-2 emerged. Furthermore, a comprehensive analysis of codon usage bias (CUB) in SARS-CoV-2 revealed significant CUB among the S-genes of different beta-coronaviruses governed majorly by natural selection and mutation pressure. Various indices of codon usage of S-genes helped in quantifying its adaptability in other animal hosts. These findings might help in identifying potential experimental animal models for investigating pathogenicity for drugs and vaccine development experiments. |*Biological Evolution[MESH] |*Codon Usage[MESH] |Angiotensin-Converting Enzyme 2/metabolism[MESH] |Animals[MESH] |Humans[MESH] |Models, Animal[MESH] |Mutation[MESH] |RNA, Transfer/genetics[MESH] |SARS-CoV-2/*genetics[MESH]Evolutionary and codon usage preference insights into spike glycoprote(epmc).pdf DeepDyve Pubget Overpricing