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10.1016/j.xcrm.2020.100146 http://scihub22266oqcxt.onion/10.1016/j.xcrm.2020.100146 33377122!7762774!33377122     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33377122&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep+Med 2020 ; 1 (9): 100146 Nephropedia Template TP {{tp|p=33377122|t=2020. Hydroxychloroquine Inhibits the Trained Innate Immune Response to Interferons |pdf=|usr=}}{{33377122}} gab.com Text Hydroxychloroquine Inhibits the Trained Innate Immune Response to Interferons JO: Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=33377122 #FOAvip Hydroxychloroquine is being investigated for a potential prophylactic effect in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but its mechanism of action is poorly understood. Circulating leukocytes from the blood of coronavirus disease 2019 (COVID-19) patients show increased responses to Toll-like receptor ligands, suggestive of trained immunity. By analyzing interferon responses of peripheral blood mononuclear cells from healthy donors conditioned with heat-killed Candida, trained innate immunity can be modeled in vitro. In this model, hydroxychloroquine inhibits the responsiveness of these innate immune cells to virus-like stimuli and interferons. This is associated with a suppression of histone 3 lysine 27 acetylation and histone 3 lysine 4 trimethylation of inflammation-related genes, changes in the cellular lipidome, and decreased expression of interferon-stimulated genes. Our findings indicate that hydroxychloroquine inhibits trained immunity in vitro, which may not be beneficial for the antiviral innate immune response to SARS-CoV-2 infection in patients. Twit Text FOAVip Hydroxychloroquine Inhibits the Trained Innate Immune Response to Interferons ????Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=33377122 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33377122 #FOAvip English Wikipedia <ref>{{Cite pmid|33377122}}</ref> Hydroxychloroquine Inhibits the Trained Innate Immune Response to Interferons #MMPMID33377122 Rother N; Yanginlar C; Lindeboom RGH; Bekkering S; van Leent MMT; Buijsers B; Jonkman I; de Graaf M; Baltissen M; Lamers LA; Riksen NP; Fayad ZA; Mulder WJM; Hilbrands LB; Joosten LAB; Netea MG; Vermeulen M; van der Vlag J; Duivenvoorden R Cell Rep Med 2020[Dec]; 1 (9): 100146 PMID33377122show ga Hydroxychloroquine is being investigated for a potential prophylactic effect in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but its mechanism of action is poorly understood. Circulating leukocytes from the blood of coronavirus disease 2019 (COVID-19) patients show increased responses to Toll-like receptor ligands, suggestive of trained immunity. By analyzing interferon responses of peripheral blood mononuclear cells from healthy donors conditioned with heat-killed Candida, trained innate immunity can be modeled in vitro. In this model, hydroxychloroquine inhibits the responsiveness of these innate immune cells to virus-like stimuli and interferons. This is associated with a suppression of histone 3 lysine 27 acetylation and histone 3 lysine 4 trimethylation of inflammation-related genes, changes in the cellular lipidome, and decreased expression of interferon-stimulated genes. Our findings indicate that hydroxychloroquine inhibits trained immunity in vitro, which may not be beneficial for the antiviral innate immune response to SARS-CoV-2 infection in patients. |COVID-19 Drug Treatment[MESH] |COVID-19/immunology[MESH] |Epigenesis, Genetic/drug effects[MESH] |Humans[MESH] |Hydroxychloroquine/*pharmacology/therapeutic use[MESH] |Immunity, Innate/*drug effects[MESH] |Immunologic Memory/*drug effects[MESH] |Immunomodulation[MESH] |Interferons/*immunology[MESH] |Leukocytes, Mononuclear/drug effects/immunology/metabolism[MESH] |Lipid Metabolism/drug effects[MESH] |SARS-CoV-2[MESH]Hydroxychloroquine Inhibits the Trained Innate Immune Response to Inte(epmc).pdf DeepDyve Pubget Overpricing