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10.1111/fcp.12643 http://scihub22266oqcxt.onion/10.1111/fcp.12643 33369768!8284663!33369768     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Fundam+Clin+Pharmacol 2021 ; 35 (2): 432-434 Nephropedia Template TP {{tp|p=33369768|t=2021. Remdesivir potently inhibits carboxylesterase-2 through covalent modifications: signifying strong drug-drug interactions |pdf=|usr=}}{{33369768}} gab.com Text Remdesivir potently inhibits carboxylesterase-2 through covalent modifications: signifying strong drug-drug interactions JO: Fundam Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33369768 #FOAvip Remdesivir was recently approved to treat COVID-19. While this antiviral agent delivers clinical benefits, several safety concerns in many cases have been raised. This study reports that remdesivir at nanomolar concentrations inhibits carboxylesterase-2 (CES2) through covalent modifications. CES2 is a major drug-metabolizing enzyme. The combination of high potency with irreversible inhibition concludes that cautions must be exercised when remdesivir is used along with drugs hydrolyzed by CES2. Twit Text FOAVip Remdesivir potently inhibits carboxylesterase-2 through covalent modifications: signifying strong drug-drug interactions ????Fundam Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33369768 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33369768 #FOAvip English Wikipedia <ref>{{Cite pmid|33369768}}</ref> Remdesivir potently inhibits carboxylesterase-2 through covalent modifications: signifying strong drug-drug interactions #MMPMID33369768 Shen Y; Eades W; Yan B Fundam Clin Pharmacol 2021[Apr]; 35 (2): 432-434 PMID33369768show ga Remdesivir was recently approved to treat COVID-19. While this antiviral agent delivers clinical benefits, several safety concerns in many cases have been raised. This study reports that remdesivir at nanomolar concentrations inhibits carboxylesterase-2 (CES2) through covalent modifications. CES2 is a major drug-metabolizing enzyme. The combination of high potency with irreversible inhibition concludes that cautions must be exercised when remdesivir is used along with drugs hydrolyzed by CES2. |Adenosine Monophosphate/adverse effects/*analogs & derivatives/pharmacology/therapeutic use[MESH] |Alanine/adverse effects/*analogs & derivatives/pharmacology/therapeutic use[MESH] |Antiviral Agents/adverse effects/*pharmacology/therapeutic use[MESH] |COVID-19 Drug Treatment[MESH] |Carboxylesterase/*antagonists & inhibitors/metabolism[MESH] |Drug Interactions[MESH] |Enzyme Inhibitors/*pharmacology[MESH] |Humans[MESH] |Microsomes/metabolism[MESH] |Pharmaceutical Preparations/metabolism[MESH]Remdesivir potently inhibits carboxylesterase-2 through covalent modif(epmc).pdf DeepDyve Pubget Overpricing