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suck abstract from ncbi


10.1111/jcmm.16230

http://scihub22266oqcxt.onion/10.1111/jcmm.16230
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33369187!7875928!33369187
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suck abstract from ncbi

pmid33369187      J+Cell+Mol+Med 2021 ; 25 (3): 1332-1341
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  • Role of gut microbiota-derived metabolites on vascular calcification in CKD #MMPMID33369187
  • Yin L; Li X; Ghosh S; Xie C; Chen J; Huang H
  • J Cell Mol Med 2021[Feb]; 25 (3): 1332-1341 PMID33369187show ga
  • The interaction between gut microbiota and the host has gained widespread concern. Gut microbiota not only provides nutrients from the ingested food but also generates bioactive metabolites and signalling molecules to impact host physiology, especially in chronic kidney disease (CKD). The development of CKD, accompanied by changed diet and medication, alters the gut flora and causes the effect in distant organs, leading to clinical complications. Vascular calcification (VC) is an actively regulated process and a high prevalence of VC in CKD has also been linked to an imbalance in gut microbiota and altered metabolites. In this review, we focused on gut microbiota-derived metabolites involved in VC in CKD and explained how these metabolites influence the calcification process. Correcting the imbalance of gut microbiota and regulating microbiota-derived metabolites by dietary modification and probiotics are new targets for the improvement of the gut-kidney axis, which indicate innovative treatment options of VC in CKD.
  • |*Disease Susceptibility[MESH]
  • |*Gastrointestinal Microbiome[MESH]
  • |*Host Microbial Interactions[MESH]
  • |Animals[MESH]
  • |Bile Acids and Salts/metabolism[MESH]
  • |Biomarkers[MESH]
  • |Diet[MESH]
  • |Disease Management[MESH]
  • |Humans[MESH]
  • |Lipid Metabolism[MESH]
  • |Renal Insufficiency, Chronic/*etiology/*metabolism/pathology/therapy[MESH]


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