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10.1093/infdis/jiaa784 http://scihub22266oqcxt.onion/10.1093/infdis/jiaa784 33367897!7798948!33367897     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Infect+Dis 2021 ; 223 (6): 957-970 Nephropedia Template TP {{tp|p=33367897|t=2021. Role of Immunoglobulin M and A Antibodies in the Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 |pdf=|usr=}}{{33367897}} gab.com Text Role of Immunoglobulin M and A Antibodies in the Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 JO: J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=33367897 #FOAvip BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected millions of people globally. Virus infection requires the receptor-binding domain (RBD) of the spike protein. Although studies have demonstrated anti-spike and -RBD antibodies to be protective in animal models, and convalescent plasma as a promising therapeutic option, little is known about immunoglobulin isotypes capable of blocking infection. METHODS: We studied spike- and RBD-specific immunoglobulin isotypes in convalescent and acute plasma/serum samples using a multiplex bead assay. We also determined virus neutralization activities in plasma and serum samples, and purified immunoglobulin fractions using a vesicular stomatitis pseudovirus assay. RESULTS: Spike- and RBD-specific immunoglobulin (Ig) M, IgG1, and IgA1 were produced by all or nearly all subjects at variable levels and detected early after infection. All samples displayed neutralizing activity. Regression analyses revealed that IgM and IgG1 contributed most to neutralization, consistent with IgM and IgG fractions' neutralization potency. IgA also exhibited neutralizing activity, but with lower potency. CONCLUSION: IgG, IgM, and IgA are critical components of convalescent plasma used for treatment of coronavirus disease 2019 (COVID-19). Twit Text FOAVip Role of Immunoglobulin M and A Antibodies in the Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 ????J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=33367897 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33367897 #FOAvip English Wikipedia <ref>{{Cite pmid|33367897}}</ref> Role of Immunoglobulin M and A Antibodies in the Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 #MMPMID33367897 Klingler J; Weiss S; Itri V; Liu X; Oguntuyo KY; Stevens C; Ikegame S; Hung CT; Enyindah-Asonye G; Amanat F; Baine I; Arinsburg S; Bandres JC; Kojic EM; Stoever J; Jurczyszak D; Bermudez-Gonzalez M; Nadas A; Liu S; Lee B; Zolla-Pazner S; Hioe CE J Infect Dis 2021[Mar]; 223 (6): 957-970 PMID33367897show ga BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected millions of people globally. Virus infection requires the receptor-binding domain (RBD) of the spike protein. Although studies have demonstrated anti-spike and -RBD antibodies to be protective in animal models, and convalescent plasma as a promising therapeutic option, little is known about immunoglobulin isotypes capable of blocking infection. METHODS: We studied spike- and RBD-specific immunoglobulin isotypes in convalescent and acute plasma/serum samples using a multiplex bead assay. We also determined virus neutralization activities in plasma and serum samples, and purified immunoglobulin fractions using a vesicular stomatitis pseudovirus assay. RESULTS: Spike- and RBD-specific immunoglobulin (Ig) M, IgG1, and IgA1 were produced by all or nearly all subjects at variable levels and detected early after infection. All samples displayed neutralizing activity. Regression analyses revealed that IgM and IgG1 contributed most to neutralization, consistent with IgM and IgG fractions' neutralization potency. IgA also exhibited neutralizing activity, but with lower potency. CONCLUSION: IgG, IgM, and IgA are critical components of convalescent plasma used for treatment of coronavirus disease 2019 (COVID-19). |Antibodies, Neutralizing/*blood[MESH] |Antibodies, Viral/*blood/immunology[MESH] |COVID-19 Serotherapy[MESH] |COVID-19 Testing[MESH] |COVID-19/diagnosis/*immunology/*therapy[MESH] |Female[MESH] |Humans[MESH] |Immunization, Passive[MESH] |Immunoglobulin A/*blood/therapeutic use[MESH] |Immunoglobulin G/blood/therapeutic use[MESH] |Immunoglobulin Isotypes/blood/therapeutic use[MESH] |Immunoglobulin M/*blood/therapeutic use[MESH] |Male[MESH] |Neutralization Tests[MESH] |SARS-CoV-2/*immunology[MESH]Role of Immunoglobulin M and A Antibodies in the Neutralization of Sev(epmc).pdf DeepDyve Pubget Overpricing