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10.1093/infdis/jiaa789

http://scihub22266oqcxt.onion/10.1093/infdis/jiaa789
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33367731!7799006!33367731
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suck abstract from ncbi


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pmid33367731      J+Infect+Dis 2021 ; 223 (6): 981-984
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  • Fostamatinib Inhibits Neutrophils Extracellular Traps Induced by COVID-19 Patient Plasma: A Potential Therapeutic #MMPMID33367731
  • Strich JR; Ramos-Benitez MJ; Randazzo D; Stein SR; Babyak A; Davey RT; Suffredini AF; Childs RW; Chertow DS
  • J Infect Dis 2021[Mar]; 223 (6): 981-984 PMID33367731show ga
  • Neutrophil extracellular traps (NETs) contribute to immunothrombosis and have been associated with mortality in coronavirus disease 2019 (COVID-19). We stimulated donor neutrophils with plasma from patients with COVID-19 and demonstrated that R406 can abrogate the release of NETs. These data provide evidence for how fostamatinib may mitigate neutrophil-associated mechanisms contributing to COVID-19 immunopathogenesis.
  • |*COVID-19 Drug Treatment[MESH]
  • |Aminopyridines[MESH]
  • |COVID-19/blood/pathology[MESH]
  • |Extracellular Traps/*drug effects[MESH]
  • |Humans[MESH]
  • |Morpholines[MESH]
  • |Neutrophils/*drug effects[MESH]
  • |Oxazines/*pharmacology[MESH]
  • |Pyridines/*pharmacology[MESH]
  • |Pyrimidines[MESH]


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