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10.1038/s41392-020-00457-4 http://scihub22266oqcxt.onion/10.1038/s41392-020-00457-4 33361761!7758413!33361761     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Signal+Transduct+Target+Ther 2020 ; 5 (1): 294 Nephropedia Template TP {{tp|p=33361761|t=2020. Longitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19 |pdf=|usr=}}{{33361761}} gab.com Text Longitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19 JO: Signal Transduct Target Ther http://www.kidney.de/pget.php?&tw=1&pmid=33361761 #FOAvip Understanding the processes of immune regulation in patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for improving treatment. Here, we performed longitudinal whole-transcriptome RNA sequencing on peripheral blood mononuclear cell (PBMC) samples from 18 patients with coronavirus disease 2019 (COVID-19) during their treatment, convalescence, and rehabilitation. After analyzing the regulatory networks of differentially expressed messenger RNAs (mRNAs), microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) between the different clinical stages, we found that humoral immunity and type I interferon response were significantly downregulated, while robust T-cell activation and differentiation at the whole transcriptome level constituted the main events that occurred during recovery from COVID-19. The formation of this T cell immune response might be driven by the activation of activating protein-1 (AP-1) related signaling pathway and was weakly affected by other clinical features. These findings uncovered the dynamic pattern of immune responses and indicated the key role of T cell immunity in the creation of immune protection against this disease. Twit Text FOAVip Longitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19 ????Signal Transduct Target Ther http://www.kidney.de/pget.php?&tw=1&pmid=33361761 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33361761 #FOAvip English Wikipedia <ref>{{Cite pmid|33361761}}</ref> Longitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19 #MMPMID33361761 Zheng HY; Xu M; Yang CX; Tian RR; Zhang M; Li JJ; Wang XC; Ding ZL; Li GM; Li XL; He YQ; Dong XQ; Yao YG; Zheng YT Signal Transduct Target Ther 2020[Dec]; 5 (1): 294 PMID33361761show ga Understanding the processes of immune regulation in patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for improving treatment. Here, we performed longitudinal whole-transcriptome RNA sequencing on peripheral blood mononuclear cell (PBMC) samples from 18 patients with coronavirus disease 2019 (COVID-19) during their treatment, convalescence, and rehabilitation. After analyzing the regulatory networks of differentially expressed messenger RNAs (mRNAs), microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) between the different clinical stages, we found that humoral immunity and type I interferon response were significantly downregulated, while robust T-cell activation and differentiation at the whole transcriptome level constituted the main events that occurred during recovery from COVID-19. The formation of this T cell immune response might be driven by the activation of activating protein-1 (AP-1) related signaling pathway and was weakly affected by other clinical features. These findings uncovered the dynamic pattern of immune responses and indicated the key role of T cell immunity in the creation of immune protection against this disease. |COVID-19/epidemiology/*genetics/pathology[MESH] |Female[MESH] |Humans[MESH] |Immunity, Humoral/*genetics/immunology[MESH] |Leukocytes, Mononuclear/metabolism[MESH] |Male[MESH] |MicroRNAs[MESH] |RNA, Long Noncoding/genetics[MESH] |RNA-Seq[MESH] |SARS-CoV-2/genetics/pathogenicity[MESH] |T-Lymphocytes/immunology/*metabolism/pathology[MESH] |Transcription Factor AP-1/genetics[MESH]Longitudinal transcriptome analyses show robust T cell immunity during(epmc).pdf DeepDyve Pubget Overpricing