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10.1016/j.biopha.2020.111138 http://scihub22266oqcxt.onion/10.1016/j.biopha.2020.111138 33360781!7973050!33360781     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+Pharmacother 2021 ; 135 (ä): 111138 Nephropedia Template TP {{tp|p=33360781|t=2021. 4-Aminoquinoline compounds from the Spanish flu to COVID-19 |pdf=|usr=}}{{33360781}} gab.com Text 4-Aminoquinoline compounds from the Spanish flu to COVID-19 JO: Biomed Pharmacother http://www.kidney.de/pget.php?&tw=1&pmid=33360781 #FOAvip In 1918, quinine was used as one of the unscientifically based treatments against the H1N1 virus during the Spanish flu pandemic. Originally, quinine was extracted from the bark of Chinchona trees by South American natives of the Amazon forest, and it has been used to treat fever since the seventeenth century. The recent COVID-19 pandemic caused by Sars-Cov-2 infection has forced researchers to search for ways to prevent and treat this disease. Based on the antiviral potential of two 4-aminoquinoline compounds derived from quinine, known as chloroquine (CQ) and hydroxychloroquine (HCQ), clinical investigations for treating COVID-19 are being conducted worldwide. However, there are some discrepancies among the clinical trial outcomes.Thus, even after one hundred years of quinine use during the Spanish flu pandemic, the antiviral properties promoted by 4-aminoquinoline compounds remain unclear. The underlying molecular mechanisms by which CQ and HCQ inhibit viral replication open up the possibility of developing novel analogs of these drugs to combat COVID-19 and other viruses. Twit Text FOAVip 4-Aminoquinoline compounds from the Spanish flu to COVID-19 ????Biomed Pharmacother http://www.kidney.de/pget.php?&tw=1&pmid=33360781 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33360781 #FOAvip English Wikipedia <ref>{{Cite pmid|33360781}}</ref> 4-Aminoquinoline compounds from the Spanish flu to COVID-19 #MMPMID33360781 Bazotte RB; Hirabara SM; Serdan TAD; Gritte RB; Souza-Siqueira T; Gorjao R; Masi LN; Antunes MM; Cruzat V; Pithon-Curi TC; Curi R Biomed Pharmacother 2021[Mar]; 135 (ä): 111138 PMID33360781show ga In 1918, quinine was used as one of the unscientifically based treatments against the H1N1 virus during the Spanish flu pandemic. Originally, quinine was extracted from the bark of Chinchona trees by South American natives of the Amazon forest, and it has been used to treat fever since the seventeenth century. The recent COVID-19 pandemic caused by Sars-Cov-2 infection has forced researchers to search for ways to prevent and treat this disease. Based on the antiviral potential of two 4-aminoquinoline compounds derived from quinine, known as chloroquine (CQ) and hydroxychloroquine (HCQ), clinical investigations for treating COVID-19 are being conducted worldwide. However, there are some discrepancies among the clinical trial outcomes.Thus, even after one hundred years of quinine use during the Spanish flu pandemic, the antiviral properties promoted by 4-aminoquinoline compounds remain unclear. The underlying molecular mechanisms by which CQ and HCQ inhibit viral replication open up the possibility of developing novel analogs of these drugs to combat COVID-19 and other viruses. |*COVID-19 Drug Treatment[MESH] |*Influenza Pandemic, 1918-1919/prevention & control[MESH] |Aminoquinolines/pharmacology/*therapeutic use[MESH] |Antimalarials/pharmacology/therapeutic use[MESH] |Antiviral Agents/pharmacology/*therapeutic use[MESH] |COVID-19/*epidemiology[MESH] |Humans[MESH] |SARS-CoV-2/*drug effects/physiology[MESH]4-Aminoquinoline compounds from the Spanish flu to COVID-19 (epmc).pdf DeepDyve Pubget Overpricing