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10.1016/j.cyto.2020.155404

http://scihub22266oqcxt.onion/10.1016/j.cyto.2020.155404
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suck abstract from ncbi


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pmid33360025      Cytokine 2021 ; 138 (ä): 155404
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  • Cytokine storm induced by SARS-CoV-2 infection: The spectrum of its neurological manifestations #MMPMID33360025
  • Thepmankorn P; Bach J; Lasfar A; Zhao X; Souayah S; Chong ZZ; Souayah N
  • Cytokine 2021[Feb]; 138 (ä): 155404 PMID33360025show ga
  • The new coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can trigger a hyperinflammatory state characterized by elevated cytokine levels known as hypercytokinemia or cytokine storm, observed most often in severe patients. Though COVID-19 is known to be a primarily respiratory disease, neurological complications affecting both the central and peripheral nervous systems have also been reported. This review discusses potential routes of SARS-CoV-2 neuroinvasion and pathogenesis, summarizes reported neurological sequelae of COVID-19, and examines how aberrant cytokine levels may precipitate these complications. Clarification of the pathogenic mechanisms of SARS-CoV-2 is needed to encourage prompt diagnosis and optimized care. In particular, identifying the presence of cytokine storm in patients with neurological COVID-19 manifestations will facilitate avenues for treatment. Future investigations into aberrant cytokine levels in COVID-19 patients with neurological symptoms as well as the efficacy of cytokine storm-targeting treatments will be critical in elucidating the pathogenic mechanisms and effective treatments of COVID-19.
  • |COVID-19/*pathology/therapy[MESH]
  • |Central Nervous System/pathology[MESH]
  • |Cerebrovascular Disorders/*pathology/virology[MESH]
  • |Cytokine Release Syndrome/*pathology/therapy[MESH]
  • |Cytokines/*blood[MESH]
  • |Humans[MESH]
  • |Nervous System Diseases/*pathology/virology[MESH]
  • |Peripheral Nervous System/pathology[MESH]


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