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  • Effects of vitamin D on macrophages and myeloid-derived suppressor cells (MDSCs) hyperinflammatory response in the lungs of COVID-19 patients #MMPMID33359760
  • Kloc M; Ghobrial RM; Lipinska-Opalka A; Wawrzyniak A; Zdanowski R; Kalicki B; Kubiak JZ
  • Cell Immunol 2021[Feb]; 360 (ä): 104259 PMID33359760show ga
  • Vitamin D regulates homeostasis, anti-microbial response, and inflammation. The vitamin D receptors are expressed in the macrophages and other immune cells, regulating the transcription of many different genes, including those coding the anti-microbial peptides. One of the most severe complications of the SARS-CoV-2 infection is the acute respiratory distress syndrome (ARDS) caused by the hyperinflammatory response (commonly called cytokine storm) of the lung macrophages. Studies showed that Vitamin D deficiency increases the severity of the ARDS in COVID-19 infection. We discuss here how the vitamin D supplementation may influence macrophage and myeloid-derived suppressor cells (MDSCs) inflammatory response, subdue the hyperinflammatory response, and lessen the ARDS in COVID-19 patients.
  • |Animals[MESH]
  • |COVID-19/complications/*drug therapy/immunology/*pathology[MESH]
  • |Child[MESH]
  • |Humans[MESH]
  • |Inflammation/drug therapy/immunology/pathology/prevention & control[MESH]
  • |Lung/immunology/*pathology[MESH]
  • |Macrophages/immunology/metabolism[MESH]
  • |Myeloid-Derived Suppressor Cells/immunology/metabolism[MESH]
  • |Receptors, Calcitriol/metabolism[MESH]
  • |Respiratory Distress Syndrome/drug therapy/immunology/pathology/prevention & control[MESH]
  • |Vitamin D/*administration & dosage[MESH]
  • |Vitamins/*administration & dosage[MESH]

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  • suck abstract from ncbi

    104259 ä.360 2021