Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.bbi.2020.12.022 http://scihub22266oqcxt.onion/10.1016/j.bbi.2020.12.022 33359380!7834471!33359380     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Brain+Behav+Immun 2021 ; 93 (ä): 415-419 Nephropedia Template TP {{tp|p=33359380|t=2021. High frequency of cerebrospinal fluid autoantibodies in COVID-19 patients with neurological symptoms |pdf=|usr=}}{{33359380}} gab.com Text High frequency of cerebrospinal fluid autoantibodies in COVID-19 patients with neurological symptoms JO: Brain Behav Immun http://www.kidney.de/pget.php?&tw=1&pmid=33359380 #FOAvip BACKGROUND: COVID-19 intensive care patients can present with neurological syndromes, usually in the absence of SARS-CoV-2 in cerebrospinal fluid (CSF). The recent finding of some virus-neutralizing antibodies cross-reacting with brain tissue suggests the possible involvement of specific autoimmunity. DESIGN: Blood and CSF samples from eleven critically ill COVID-19 patients presenting with unexplained neurological symptoms including myoclonus, oculomotor disturbance, delirium, dystonia and epileptic seizures, were analyzed for anti-neuronal and anti-glial autoantibodies. RESULTS: Using cell-based assays and indirect immunofluorescence on unfixed murine brain sections, all patients showed anti-neuronal autoantibodies in serum or CSF. Antigens included intracellular and neuronal surface proteins, such as Yo or NMDA receptor, but also various specific undetermined epitopes, reminiscent of the brain tissue binding observed with certain human monoclonal SARS-CoV-2 antibodies. These included vessel endothelium, astrocytic proteins and neuropil of basal ganglia, hippocampus or olfactory bulb. CONCLUSION: The high frequency of autoantibodies targeting the brain in the absence of other explanations suggests a causal relationship to clinical symptoms, in particular to hyperexcitability (myoclonus, seizures). Several underlying autoantigens and their potential molecular mimicry with SARS-CoV-2 still await identification. However, autoantibodies may already now explain some aspects of multi-organ disease in COVID-19 and can guide immunotherapy in selected cases. Twit Text FOAVip High frequency of cerebrospinal fluid autoantibodies in COVID-19 patients with neurological symptoms ????Brain Behav Immun http://www.kidney.de/pget.php?&tw=1&pmid=33359380 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33359380 #FOAvip English Wikipedia <ref>{{Cite pmid|33359380}}</ref> High frequency of cerebrospinal fluid autoantibodies in COVID-19 patients with neurological symptoms #MMPMID33359380 Franke C; Ferse C; Kreye J; Reincke SM; Sanchez-Sendin E; Rocco A; Steinbrenner M; Angermair S; Treskatsch S; Zickler D; Eckardt KU; Dersch R; Hosp J; Audebert HJ; Endres M; Ploner JC; Pruss H Brain Behav Immun 2021[Mar]; 93 (ä): 415-419 PMID33359380show ga BACKGROUND: COVID-19 intensive care patients can present with neurological syndromes, usually in the absence of SARS-CoV-2 in cerebrospinal fluid (CSF). The recent finding of some virus-neutralizing antibodies cross-reacting with brain tissue suggests the possible involvement of specific autoimmunity. DESIGN: Blood and CSF samples from eleven critically ill COVID-19 patients presenting with unexplained neurological symptoms including myoclonus, oculomotor disturbance, delirium, dystonia and epileptic seizures, were analyzed for anti-neuronal and anti-glial autoantibodies. RESULTS: Using cell-based assays and indirect immunofluorescence on unfixed murine brain sections, all patients showed anti-neuronal autoantibodies in serum or CSF. Antigens included intracellular and neuronal surface proteins, such as Yo or NMDA receptor, but also various specific undetermined epitopes, reminiscent of the brain tissue binding observed with certain human monoclonal SARS-CoV-2 antibodies. These included vessel endothelium, astrocytic proteins and neuropil of basal ganglia, hippocampus or olfactory bulb. CONCLUSION: The high frequency of autoantibodies targeting the brain in the absence of other explanations suggests a causal relationship to clinical symptoms, in particular to hyperexcitability (myoclonus, seizures). Several underlying autoantigens and their potential molecular mimicry with SARS-CoV-2 still await identification. However, autoantibodies may already now explain some aspects of multi-organ disease in COVID-19 and can guide immunotherapy in selected cases. |Aged[MESH] |Autoantibodies/*cerebrospinal fluid[MESH] |Autoantigens[MESH] |Autoimmunity[MESH] |COVID-19/*cerebrospinal fluid[MESH] |Central Nervous System Diseases/*virology[MESH] |Female[MESH] |Humans[MESH] |Male[MESH]High frequency of cerebrospinal fluid autoantibodies in COVID-19 patie(epmc).pdf DeepDyve Pubget Overpricing