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10.1016/j.jsat.2020.108197

http://scihub22266oqcxt.onion/10.1016/j.jsat.2020.108197
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33357606!7834258!33357606
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suck abstract from ncbi


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pmid33357606      J+Subst+Abuse+Treat 2021 ; 121 (ä): 108197
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  • Technology-assisted methadone take-home dosing for dispensing methadone to persons with opioid use disorder during the Covid-19 pandemic #MMPMID33357606
  • Dunn KE; Brooner RK; Stoller KB
  • J Subst Abuse Treat 2021[Feb]; 121 (ä): 108197 PMID33357606show ga
  • INTRODUCTION: Covid-19 confers substantial risk for the >400,000 patients who receive methadone for the treatment of opioid use disorder (OUD) and methods for safely dispensing large quantities of methadone to patients are lacking. METHODS: This study evaluated the MedMinder "Jon", an electronic and cellular-enabled pillbox that provides real-time monitoring to remotely manage take-home doses of methadone using a 12-week, within-subject, Phase II (NCT03254043) trial. We transitioned all participants from liquid to tablet methadone one week prior to randomization. Participants completed both treatment-as-usual and electronic pillbox conditions before choosing a condition in a final "choice phase". We assessed feasibility, satisfaction, and safety outcomes during the exit interview. RESULTS: Overall, we randomized 25 participants, 24 (96.0%) completed >1 study session, and 21 (84.0%) completed the exit interview. We dispensed 167.92 g (1,974 doses) of methadone. Participants would use the pillbox again (86.3%) and recommend it to others (95.4%). Overall, 52.4% selected the pillbox in the choice condition and those who did not cited issues related to study requirements. Less than 1% of pillbox alerts were for medication being consumed outside the dosing window and we observed no evidence of actual or attempted methadone diversion. DISCUSSION: We were able to adequately manage patients who would not otherwise qualify for large quantities of take-home methadone when we dispensed methadone tablets via a secure pillbox. The integration of a commercially available pillbox into routine clinic operations increases opportunity for dispensing medication. Our data support remote monitoring of methadone take-home doses and may inform clinic practices related to Covid-19.
  • |*COVID-19[MESH]
  • |*Self-Help Devices[MESH]
  • |Adult[MESH]
  • |Analgesics, Opioid/*therapeutic use[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Medication Adherence[MESH]
  • |Methadone/*therapeutic use[MESH]
  • |Opiate Substitution Treatment[MESH]
  • |Opioid-Related Disorders/*rehabilitation[MESH]


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