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10.1016/j.chom.2020.12.009 http://scihub22266oqcxt.onion/10.1016/j.chom.2020.12.009 33357464!7833927!33357464     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33357464.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Host+Microbe 2021 ; 29 (2): 267-280.e5 Nephropedia Template TP {{tp|p=33357464|t=2021. Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors |pdf=|usr=}}{{33357464}} gab.com Text Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors JO: Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=33357464 #FOAvip The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has devastated the global economy and claimed more than 1.7 million lives, presenting an urgent global health crisis. To identify host factors required for infection by SARS-CoV-2 and seasonal coronaviruses, we designed a focused high-coverage CRISPR-Cas9 library targeting 332 members of a recently published SARS-CoV-2 protein interactome. We leveraged the compact nature of this library to systematically screen SARS-CoV-2 at two physiologically relevant temperatures along with three related coronaviruses (human coronavirus 229E [HCoV-229E], HCoV-NL63, and HCoV-OC43), allowing us to probe this interactome at a much higher resolution than genome-scale studies. This approach yielded several insights, including potential virus-specific differences in Rab GTPase requirements and glycosylphosphatidylinositol (GPI) anchor biosynthesis, as well as identification of multiple pan-coronavirus factors involved in cholesterol homeostasis. This coronavirus essentiality catalog could inform ongoing drug development efforts aimed at intercepting and treating coronavirus disease 2019 (COVID-19) and help prepare for future coronavirus outbreaks. Twit Text FOAVip Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors ????Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=33357464 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33357464 #FOAvip English Wikipedia <ref>{{Cite pmid|33357464}}</ref> Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors #MMPMID33357464 Hoffmann HH; Sanchez-Rivera FJ; Schneider WM; Luna JM; Soto-Feliciano YM; Ashbrook AW; Le Pen J; Leal AA; Ricardo-Lax I; Michailidis E; Hao Y; Stenzel AF; Peace A; Zuber J; Allis CD; Lowe SW; MacDonald MR; Poirier JT; Rice CM Cell Host Microbe 2021[Feb]; 29 (2): 267-280.e5 PMID33357464show ga The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has devastated the global economy and claimed more than 1.7 million lives, presenting an urgent global health crisis. To identify host factors required for infection by SARS-CoV-2 and seasonal coronaviruses, we designed a focused high-coverage CRISPR-Cas9 library targeting 332 members of a recently published SARS-CoV-2 protein interactome. We leveraged the compact nature of this library to systematically screen SARS-CoV-2 at two physiologically relevant temperatures along with three related coronaviruses (human coronavirus 229E [HCoV-229E], HCoV-NL63, and HCoV-OC43), allowing us to probe this interactome at a much higher resolution than genome-scale studies. This approach yielded several insights, including potential virus-specific differences in Rab GTPase requirements and glycosylphosphatidylinositol (GPI) anchor biosynthesis, as well as identification of multiple pan-coronavirus factors involved in cholesterol homeostasis. This coronavirus essentiality catalog could inform ongoing drug development efforts aimed at intercepting and treating coronavirus disease 2019 (COVID-19) and help prepare for future coronavirus outbreaks. |COVID-19/*virology[MESH] |CRISPR-Cas Systems[MESH] |Coronavirus 229E, Human/genetics/metabolism[MESH] |Coronavirus NL63, Human/genetics/metabolism[MESH] |Coronavirus OC43, Human[MESH] |Genes, Viral[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |SARS-CoV-2/genetics/*metabolism[MESH]Functional interrogation of a SARS-CoV-2 host protein interactome iden(epmc).pdf DeepDyve Pubget Overpricing