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10.1016/j.celrep.2020.108590 http://scihub22266oqcxt.onion/10.1016/j.celrep.2020.108590 33357411!7744012!33357411     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33357411.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Rep 2021 ; 34 (1): 108590 Nephropedia Template TP {{tp|p=33357411|t=2021. Cell-Type-Specific Immune Dysregulation in Severely Ill COVID-19 Patients |pdf=|usr=}}{{33357411}} gab.com Text Cell-Type-Specific Immune Dysregulation in Severely Ill COVID-19 Patients JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=33357411 #FOAvip Recent studies have demonstrated immunologic dysfunction in severely ill coronavirus disease 2019 (COVID-19) patients. We use single-cell RNA sequencing (scRNA-seq) to analyze the transcriptome of peripheral blood mononuclear cells (PBMCs) from healthy (n = 3) and COVID-19 patients with moderate disease (n = 5), acute respiratory distress syndrome (ARDS, n = 6), or recovering from ARDS (n = 6). Our data reveal transcriptomic profiles indicative of defective antigen presentation and interferon (IFN) responsiveness in monocytes from ARDS patients, which contrasts with higher responsiveness to IFN signaling in lymphocytes. Furthermore, genes involved in cytotoxic activity are suppressed in both natural killer (NK) and CD8 T lymphocytes, and B cell activation is deficient, which is consistent with delayed viral clearance in severely ill COVID-19 patients. Our study demonstrates that COVID-19 patients with ARDS have a state of immune imbalance in which dysregulation of both innate and adaptive immune responses may be contributing to a more severe disease course. Twit Text FOAVip Cell-Type-Specific Immune Dysregulation in Severely Ill COVID-19 Patients ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=33357411 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33357411 #FOAvip English Wikipedia <ref>{{Cite pmid|33357411}}</ref> Cell-Type-Specific Immune Dysregulation in Severely Ill COVID-19 Patients #MMPMID33357411 Yao C; Bora SA; Parimon T; Zaman T; Friedman OA; Palatinus JA; Surapaneni NS; Matusov YP; Cerro Chiang G; Kassar AG; Patel N; Green CER; Aziz AW; Suri H; Suda J; Lopez AA; Martins GA; Stripp BR; Gharib SA; Goodridge HS; Chen P Cell Rep 2021[Jan]; 34 (1): 108590 PMID33357411show ga Recent studies have demonstrated immunologic dysfunction in severely ill coronavirus disease 2019 (COVID-19) patients. We use single-cell RNA sequencing (scRNA-seq) to analyze the transcriptome of peripheral blood mononuclear cells (PBMCs) from healthy (n = 3) and COVID-19 patients with moderate disease (n = 5), acute respiratory distress syndrome (ARDS, n = 6), or recovering from ARDS (n = 6). Our data reveal transcriptomic profiles indicative of defective antigen presentation and interferon (IFN) responsiveness in monocytes from ARDS patients, which contrasts with higher responsiveness to IFN signaling in lymphocytes. Furthermore, genes involved in cytotoxic activity are suppressed in both natural killer (NK) and CD8 T lymphocytes, and B cell activation is deficient, which is consistent with delayed viral clearance in severely ill COVID-19 patients. Our study demonstrates that COVID-19 patients with ARDS have a state of immune imbalance in which dysregulation of both innate and adaptive immune responses may be contributing to a more severe disease course. |*Transcriptome[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Antigen Presentation[MESH] |COVID-19/complications/*immunology/pathology[MESH] |Female[MESH] |Humans[MESH] |Interferons/metabolism[MESH] |Lymphocyte Activation[MESH] |Lymphocyte Subsets/*immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Monocytes/metabolism[MESH] |RNA-Seq[MESH]Cell-Type-Specific Immune Dysregulation in Severely Ill COVID-19 Patie(epmc).pdf DeepDyve Pubget Overpricing