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10.1016/j.celrep.2020.108590

http://scihub22266oqcxt.onion/10.1016/j.celrep.2020.108590
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33357411!7744012!33357411
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suck abstract from ncbi


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pmid33357411      Cell+Rep 2021 ; 34 (1): 108590
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  • Cell-Type-Specific Immune Dysregulation in Severely Ill COVID-19 Patients #MMPMID33357411
  • Yao C; Bora SA; Parimon T; Zaman T; Friedman OA; Palatinus JA; Surapaneni NS; Matusov YP; Cerro Chiang G; Kassar AG; Patel N; Green CER; Aziz AW; Suri H; Suda J; Lopez AA; Martins GA; Stripp BR; Gharib SA; Goodridge HS; Chen P
  • Cell Rep 2021[Jan]; 34 (1): 108590 PMID33357411show ga
  • Recent studies have demonstrated immunologic dysfunction in severely ill coronavirus disease 2019 (COVID-19) patients. We use single-cell RNA sequencing (scRNA-seq) to analyze the transcriptome of peripheral blood mononuclear cells (PBMCs) from healthy (n = 3) and COVID-19 patients with moderate disease (n = 5), acute respiratory distress syndrome (ARDS, n = 6), or recovering from ARDS (n = 6). Our data reveal transcriptomic profiles indicative of defective antigen presentation and interferon (IFN) responsiveness in monocytes from ARDS patients, which contrasts with higher responsiveness to IFN signaling in lymphocytes. Furthermore, genes involved in cytotoxic activity are suppressed in both natural killer (NK) and CD8 T lymphocytes, and B cell activation is deficient, which is consistent with delayed viral clearance in severely ill COVID-19 patients. Our study demonstrates that COVID-19 patients with ARDS have a state of immune imbalance in which dysregulation of both innate and adaptive immune responses may be contributing to a more severe disease course.
  • |*Transcriptome[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Antigen Presentation[MESH]
  • |COVID-19/complications/*immunology/pathology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Interferons/metabolism[MESH]
  • |Lymphocyte Activation[MESH]
  • |Lymphocyte Subsets/*immunology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Monocytes/metabolism[MESH]
  • |RNA-Seq[MESH]


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