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10.1016/j.immuni.2020.12.001 http://scihub22266oqcxt.onion/10.1016/j.immuni.2020.12.001 33357409!7836640!33357409     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33357409&cmd=llinks): Failed to open stream: HTTP request failed! 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The persistence of interleukin-6 is regulated by a blood buffer system derived from dendritic cells |pdf=|usr=}}{{33357409}} gab.com Text The persistence of interleukin-6 is regulated by a blood buffer system derived from dendritic cells JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=33357409 #FOAvip The interleukin-6 (IL-6) membrane receptor and its circulating soluble form, sIL-6R, can be targeted by antibody therapy to reduce deleterious immune signaling caused by chronic overexpression of the pro-inflammatory cytokine IL-6. This strategy may also hold promise for treating acute hyperinflammation, such as observed in coronavirus disease 2019 (COVID-19), highlighting a need to define regulators of IL-6 homeostasis. We found that conventional dendritic cells (cDCs), defined in mice via expression of the transcription factor Zbtb46, were a major source of circulating sIL-6R and, thus, systemically regulated IL-6 signaling. This was uncovered through identification of a cDC-dependent but T cell-independent modality that naturally adjuvants plasma cell differentiation and antibody responses to protein antigens. This pathway was then revealed as part of a broader biological buffer system in which cDC-derived sIL-6R set the in-solution persistence of IL-6. This control axis may further inform the development of therapeutic agents to modulate pro-inflammatory immune reactions. Twit Text FOAVip The persistence of interleukin-6 is regulated by a blood buffer system derived from dendritic cells ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=33357409 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33357409 #FOAvip English Wikipedia <ref>{{Cite pmid|33357409}}</ref> The persistence of interleukin-6 is regulated by a blood buffer system derived from dendritic cells #MMPMID33357409 Yousif AS; Ronsard L; Shah P; Omatsu T; Sangesland M; Bracamonte Moreno T; Lam EC; Vrbanac VD; Balazs AB; Reinecker HC; Lingwood D Immunity 2021[Feb]; 54 (2): 235-246.e5 PMID33357409show ga The interleukin-6 (IL-6) membrane receptor and its circulating soluble form, sIL-6R, can be targeted by antibody therapy to reduce deleterious immune signaling caused by chronic overexpression of the pro-inflammatory cytokine IL-6. This strategy may also hold promise for treating acute hyperinflammation, such as observed in coronavirus disease 2019 (COVID-19), highlighting a need to define regulators of IL-6 homeostasis. We found that conventional dendritic cells (cDCs), defined in mice via expression of the transcription factor Zbtb46, were a major source of circulating sIL-6R and, thus, systemically regulated IL-6 signaling. This was uncovered through identification of a cDC-dependent but T cell-independent modality that naturally adjuvants plasma cell differentiation and antibody responses to protein antigens. This pathway was then revealed as part of a broader biological buffer system in which cDC-derived sIL-6R set the in-solution persistence of IL-6. This control axis may further inform the development of therapeutic agents to modulate pro-inflammatory immune reactions. |ADAM17 Protein[MESH] |Animals[MESH] |Cell Differentiation[MESH] |Dendritic Cells/*immunology[MESH] |Immunity, Humoral[MESH] |Immunoglobulin M/immunology[MESH] |Inflammation[MESH] |Interferon Regulatory Factors/genetics/immunology[MESH] |Interleukin-6/*blood/genetics/*immunology[MESH] |Membrane Glycoproteins/immunology[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Mice, Transgenic[MESH] |Plasma Cells/immunology[MESH] |Receptors, Interleukin-6/blood/immunology[MESH] |Signal Transduction/immunology[MESH] |Toll-Like Receptor 4/immunology[MESH]The persistence of interleukin-6 is regulated by a blood buffer system(epmc).pdf DeepDyve Pubget Overpricing