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10.7861/clinmed.2020-0614

http://scihub22266oqcxt.onion/10.7861/clinmed.2020-0614
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33355197!7850181!33355197
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suck abstract from ncbi


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pmid33355197      Clin+Med+(Lond) 2021 ; 21 (1): e71-e76
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  • Use of procalcitonin for antibiotic stewardship in patients with COVID-19: A quality improvement project in a district general hospital #MMPMID33355197
  • Peters C; Williams K; Un EA; Little L; Saad A; Lendrum K; Thompson N; Weatherley ND; Pegden A
  • Clin Med (Lond) 2021[Jan]; 21 (1): e71-e76 PMID33355197show ga
  • Antibiotic stewardship during the COVID-19 pandemic is an important part of a comprehensive strategy to improve patient outcomes and reduce long-term adverse effects secondary to rising antibiotic resistance. This report describes a quality improvement project which incorporates the use of procalcitonin (PCT) testing to rationalise antibiotic prescribing in patients with suspected or confirmed COVID-19 at Chesterfield Royal Hospital. Data were collected from 118 patients with a total of 127 PCT levels checked over a period of 20 days. Each PCT level was correlated with the subsequent antibiotic outcome as well as the result of the COVID-19 PCR swab. Results indicate that antibiotics were either never started or were stopped within 48 hours in 72% of COVID-confirmed cases with a PCT less than 0.25 mug/L. Our findings suggest that procalcitonin testing, when used in combination with thorough clinical assessment, is a safe, simple and sustainable way of reducing antibiotic use in COVID-19.
  • |*COVID-19 Drug Treatment[MESH]
  • |*Hospitals, District[MESH]
  • |Anti-Bacterial Agents/*therapeutic use[MESH]
  • |COVID-19/epidemiology/virology[MESH]
  • |Drug Resistance, Bacterial/*drug effects[MESH]
  • |Female[MESH]
  • |Follow-Up Studies[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Procalcitonin/*therapeutic use[MESH]
  • |RNA, Viral/*analysis[MESH]
  • |Retrospective Studies[MESH]


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