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Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Clin+Med+(Lond) 2021 ; 21 (1): e71-e76 Nephropedia Template TP
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Use of procalcitonin for antibiotic stewardship in patients with COVID-19: A quality improvement project in a district general hospital #MMPMID33355197
Peters C; Williams K; Un EA; Little L; Saad A; Lendrum K; Thompson N; Weatherley ND; Pegden A
Clin Med (Lond) 2021[Jan]; 21 (1): e71-e76 PMID33355197show ga
Antibiotic stewardship during the COVID-19 pandemic is an important part of a comprehensive strategy to improve patient outcomes and reduce long-term adverse effects secondary to rising antibiotic resistance. This report describes a quality improvement project which incorporates the use of procalcitonin (PCT) testing to rationalise antibiotic prescribing in patients with suspected or confirmed COVID-19 at Chesterfield Royal Hospital. Data were collected from 118 patients with a total of 127 PCT levels checked over a period of 20 days. Each PCT level was correlated with the subsequent antibiotic outcome as well as the result of the COVID-19 PCR swab. Results indicate that antibiotics were either never started or were stopped within 48 hours in 72% of COVID-confirmed cases with a PCT less than 0.25 mug/L. Our findings suggest that procalcitonin testing, when used in combination with thorough clinical assessment, is a safe, simple and sustainable way of reducing antibiotic use in COVID-19.