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10.1016/j.jcv.2020.104713 http://scihub22266oqcxt.onion/10.1016/j.jcv.2020.104713 33352470!7832367!33352470     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Virol 2021 ; 135 (ä): 104713 Nephropedia Template TP {{tp|p=33352470|t=2021. Evaluation of a SARS-CoV-2 rapid antigen test: Potential to help reduce community spread?|pdf=|usr=}}{{33352470}} gab.com Text Evaluation of a SARS-CoV-2 rapid antigen test: Potential to help reduce community spread JO: J Clin Virol http://www.kidney.de/pget.php?&tw=1&pmid=33352470 #FOAvip BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can spread from symptomatic patients with COVID-19, but also from asymptomatic individuals. Therefore, robust surveillance and timely interventions are essential for the control of virus spread within the community. In this regard the frequency of testing and speed of reporting, but not the test sensitivity alone, play a crucial role. OBJECTIVES: In order to reduce the costs and meet the expanding demands in real-time RT-PCR (rRT-PCR) testing for SARS-CoV-2, complementary assays, such as rapid antigen tests, have been developed. Rigorous analysis under varying conditions is required to assess the clinical performance of these tests and to ensure reproducible results. RESULTS: We evaluated the sensitivity and specificity of a recently licensed rapid antigen test using 137 clinical samples in two institutions. Test sensitivity was between 88.2-89.6 % when applied to samples with viral loads typically seen in infectious patients. Of 32 rRT-PCR positive samples, 19 demonstrated infectivity in cell culture, and 84 % of these samples were reactive with the antigen test. Seven full-genome sequenced SARS-CoV-2 isolates and SARS-CoV-1 were detected with this antigen test, with no cross-reactivity against other common respiratory viruses. CONCLUSIONS: Numerous antigen tests are available for SARS-CoV-2 testing and their performance to detect infectious individuals may vary. Head-to-head comparison along with cell culture testing for infectivity may prove useful to identify better performing antigen tests. The antigen test analyzed in this study is easy-to-use, inexpensive, and scalable. It can be helpful in monitoring infection trends and thus has potential to reduce transmission. Twit Text FOAVip Evaluation of a SARS-CoV-2 rapid antigen test: Potential to help reduce community spread ????J Clin Virol http://www.kidney.de/pget.php?&tw=1&pmid=33352470 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33352470 #FOAvip English Wikipedia <ref>{{Cite pmid|33352470}}</ref> Evaluation of a SARS-CoV-2 rapid antigen test: Potential to help reduce community spread? #MMPMID33352470 Toptan T; Eckermann L; Pfeiffer AE; Hoehl S; Ciesek S; Drosten C; Corman VM J Clin Virol 2021[Feb]; 135 (ä): 104713 PMID33352470show ga BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can spread from symptomatic patients with COVID-19, but also from asymptomatic individuals. Therefore, robust surveillance and timely interventions are essential for the control of virus spread within the community. In this regard the frequency of testing and speed of reporting, but not the test sensitivity alone, play a crucial role. OBJECTIVES: In order to reduce the costs and meet the expanding demands in real-time RT-PCR (rRT-PCR) testing for SARS-CoV-2, complementary assays, such as rapid antigen tests, have been developed. Rigorous analysis under varying conditions is required to assess the clinical performance of these tests and to ensure reproducible results. RESULTS: We evaluated the sensitivity and specificity of a recently licensed rapid antigen test using 137 clinical samples in two institutions. Test sensitivity was between 88.2-89.6 % when applied to samples with viral loads typically seen in infectious patients. Of 32 rRT-PCR positive samples, 19 demonstrated infectivity in cell culture, and 84 % of these samples were reactive with the antigen test. Seven full-genome sequenced SARS-CoV-2 isolates and SARS-CoV-1 were detected with this antigen test, with no cross-reactivity against other common respiratory viruses. CONCLUSIONS: Numerous antigen tests are available for SARS-CoV-2 testing and their performance to detect infectious individuals may vary. Head-to-head comparison along with cell culture testing for infectivity may prove useful to identify better performing antigen tests. The antigen test analyzed in this study is easy-to-use, inexpensive, and scalable. It can be helpful in monitoring infection trends and thus has potential to reduce transmission. |Antigens, Viral/*genetics[MESH] |COVID-19 Serological Testing/*methods[MESH] |COVID-19/*diagnosis/virology[MESH] |Caco-2 Cells[MESH] |Cell Line, Tumor[MESH] |Cells, Cultured[MESH] |Genome, Viral/genetics[MESH] |Humans[MESH] |Real-Time Polymerase Chain Reaction/methods[MESH] |Reproducibility of Results[MESH] |SARS-CoV-2/*genetics[MESH] |Sensitivity and Specificity[MESH]Evaluation of a SARS-CoV-2 rapid antigen test: Potential to help reduc(epmc).pdf DeepDyve Pubget Overpricing