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Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Emerg+Infect+Dis 2021 ; 27 (1): 196-204 Nephropedia Template TP
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Territorywide Study of Early Coronavirus Disease Outbreak, Hong Kong, China #MMPMID33350913
Leung KS; Ng TT; Wu AK; Yau MC; Lao HY; Choi MP; Tam KK; Lee LK; Wong BK; Man Ho AY; Yip KT; Lung KC; Liu RW; Tso EY; Leung WS; Chan MC; Ng YY; Sin KM; Fung KS; Chau SK; To WK; Que TL; Shum DH; Yip SP; Yam WC; Siu GK
Emerg Infect Dis 2021[Jan]; 27 (1): 196-204 PMID33350913show ga
Initial cases of coronavirus disease in Hong Kong were imported from mainland China. A dramatic increase in case numbers was seen in February 2020. Most case-patients had no recent travel history, suggesting the presence of transmission chains in the local community. We collected demographic, clinical, and epidemiologic data from 50 patients, who accounted for 53.8% of total reported case-patients as of February 28, 2020. We performed whole-genome sequencing to determine phylogenetic relationship and transmission dynamics of severe acute respiratory syndrome coronavirus 2 infections. By using phylogenetic analysis, we attributed the community outbreak to 2 lineages; 1 harbored a common mutation, Orf3a-G251V, and accounted for 88.0% of the cases in our study. The estimated time to the most recent common ancestor of local coronavirus disease outbreak was December 24, 2019, with an evolutionary rate of 3.04 x 10(-3) substitutions/site/year. The reproduction number was 1.84, indicating ongoing community spread.