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10.1016/j.cyto.2020.155389 http://scihub22266oqcxt.onion/10.1016/j.cyto.2020.155389 33348065!7833204!33348065     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33348065&cmd=llinks): Failed to open stream: HTTP request failed! 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Increased levels of plasma cytokines and correlations to organ failure and 30-day mortality in critically ill Covid-19 patients |pdf=|usr=}}{{33348065}} gab.com Text Increased levels of plasma cytokines and correlations to organ failure and 30-day mortality in critically ill Covid-19 patients JO: Cytokine http://www.kidney.de/pget.php?&tw=1&pmid=33348065 #FOAvip BACKGROUND: The infection caused by SARS CoV-2 has been postulated to induce a cytokine storm syndrome that results in organ failure and even death in a considerable number of patients. However, the inflammatory response in Corona virus disease-19 (Covid-19) and its potential to cause collateral organ damage has not been fully elucidated to date. This study aims to characterize the acute cytokine response in a cohort of critically ill Covid-19 patients. METHOD: 24 adults with PCR-confirmed Covid-19 were included at time of admission to intensive care a median of eleven days after initial symptoms. Eleven adult patients admitted for elective abdominal surgery with preoperative plasma samples served as controls. All patients were included after informed consent was obtained. 27 cytokines were quantified in plasma. The expression of inflammatory mediators was then related to routine inflammatory markers, SAPS3, SOFA score, organ failure and 30-day mortality. RESULTS: A general increase in cytokine expression was observed in all Covid-19 patients. A strong correlation between respiratory failure and IL-1ra, IL-4, IL-6, IL-8 and IP-10 expression was observed. Acute kidney injury development correlated well with increased levels of IL-1ra, IL-6, IL-8, IL-17a, IP-10 and MCP-1. Generally, the cohort demonstrated weaker correlations between cytokine expression and 30-day mortality out of which IL-8 showed the strongest signal in terms of mortality. CONCLUSION: The present study found that respiratory failure, acute kidney injury and 30-day mortality in critically ill Covid-19 patients are associated with moderate increases of a broad range of inflammatory mediators at time of admission. Twit Text FOAVip Increased levels of plasma cytokines and correlations to organ failure and 30-day mortality in critically ill Covid-19 patients ????Cytokine http://www.kidney.de/pget.php?&tw=1&pmid=33348065 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33348065 #FOAvip English Wikipedia <ref>{{Cite pmid|33348065}}</ref> Increased levels of plasma cytokines and correlations to organ failure and 30-day mortality in critically ill Covid-19 patients #MMPMID33348065 Bulow Anderberg S; Luther T; Berglund M; Larsson R; Rubertsson S; Lipcsey M; Larsson A; Frithiof R; Hultstrom M Cytokine 2021[Feb]; 138 (ä): 155389 PMID33348065show ga BACKGROUND: The infection caused by SARS CoV-2 has been postulated to induce a cytokine storm syndrome that results in organ failure and even death in a considerable number of patients. However, the inflammatory response in Corona virus disease-19 (Covid-19) and its potential to cause collateral organ damage has not been fully elucidated to date. This study aims to characterize the acute cytokine response in a cohort of critically ill Covid-19 patients. METHOD: 24 adults with PCR-confirmed Covid-19 were included at time of admission to intensive care a median of eleven days after initial symptoms. Eleven adult patients admitted for elective abdominal surgery with preoperative plasma samples served as controls. All patients were included after informed consent was obtained. 27 cytokines were quantified in plasma. The expression of inflammatory mediators was then related to routine inflammatory markers, SAPS3, SOFA score, organ failure and 30-day mortality. RESULTS: A general increase in cytokine expression was observed in all Covid-19 patients. A strong correlation between respiratory failure and IL-1ra, IL-4, IL-6, IL-8 and IP-10 expression was observed. Acute kidney injury development correlated well with increased levels of IL-1ra, IL-6, IL-8, IL-17a, IP-10 and MCP-1. Generally, the cohort demonstrated weaker correlations between cytokine expression and 30-day mortality out of which IL-8 showed the strongest signal in terms of mortality. CONCLUSION: The present study found that respiratory failure, acute kidney injury and 30-day mortality in critically ill Covid-19 patients are associated with moderate increases of a broad range of inflammatory mediators at time of admission. |Acute Kidney Injury/*pathology/virology[MESH] |Aged[MESH] |Biomarkers/blood[MESH] |COVID-19/blood/mortality/*pathology[MESH] |Critical Illness[MESH] |Cytokine Release Syndrome/*mortality/pathology[MESH] |Cytokines/*blood[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Respiratory Insufficiency/*pathology/virology[MESH]Increased levels of plasma cytokines and correlations to organ failure(epmc).pdf DeepDyve Pubget Overpricing