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10.1016/j.ijantimicag.2020.106272 http://scihub22266oqcxt.onion/10.1016/j.ijantimicag.2020.106272 33347989!7755579!33347989     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Antimicrob+Agents 2021 ; 57 (2): 106272 Nephropedia Template TP {{tp|p=33347989|t=2021. Different mutations in SARS-CoV-2 associate with severe and mild outcome |pdf=|usr=}}{{33347989}} gab.com Text Different mutations in SARS-CoV-2 associate with severe and mild outcome JO: Int J Antimicrob Agents http://www.kidney.de/pget.php?&tw=1&pmid=33347989 #FOAvip INTRODUCTION: Genomic alterations in a viral genome can lead to either better or worse outcome and identifying these mutations is of utmost importance. Here, we correlated protein-level mutations in the SARS-CoV-2 virus to clinical outcome. METHODS: Mutations in viral sequences from the GISAID virus repository were evaluated by using "hCoV-19/Wuhan/WIV04/2019" as the reference. Patient outcomes were classified as mild disease, hospitalization and severe disease (death or documented treatment in an intensive-care unit). Chi-square test was applied to examine the association between each mutation and patient outcome. False discovery rate was computed to correct for multiple hypothesis testing and results passing FDR cutoff of 5% were accepted as significant. RESULTS: Mutations were mapped to amino acid changes for 3,733 non-silent mutations. Mutations correlated to mild outcome were located in the ORF8, NSP6, ORF3a, NSP4, and in the nucleocapsid phosphoprotein N. Mutations associated with inferior outcome were located in the surface (S) glycoprotein, in the RNA dependent RNA polymerase, in ORF3a, NSP3, ORF6 and N. Mutations leading to severe outcome with low prevalence were found in the ORF3A and in NSP7 proteins. Four out of 22 of the most significant mutations mapped onto a 10 amino acid long phosphorylated stretch of N indicating that in spite of obvious sampling restrictions the approach can find functionally relevant sites in the viral genome. CONCLUSIONS: We demonstrate that mutations in the viral genes may have a direct correlation to clinical outcome. Our results help to quickly identify SARS-CoV-2 infections harboring mutations related to severe outcome. Twit Text FOAVip Different mutations in SARS-CoV-2 associate with severe and mild outcome ????Int J Antimicrob Agents http://www.kidney.de/pget.php?&tw=1&pmid=33347989 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33347989 #FOAvip English Wikipedia <ref>{{Cite pmid|33347989}}</ref> Different mutations in SARS-CoV-2 associate with severe and mild outcome #MMPMID33347989 Nagy A; Pongor S; Gyorffy B Int J Antimicrob Agents 2021[Feb]; 57 (2): 106272 PMID33347989show ga INTRODUCTION: Genomic alterations in a viral genome can lead to either better or worse outcome and identifying these mutations is of utmost importance. Here, we correlated protein-level mutations in the SARS-CoV-2 virus to clinical outcome. METHODS: Mutations in viral sequences from the GISAID virus repository were evaluated by using "hCoV-19/Wuhan/WIV04/2019" as the reference. Patient outcomes were classified as mild disease, hospitalization and severe disease (death or documented treatment in an intensive-care unit). Chi-square test was applied to examine the association between each mutation and patient outcome. False discovery rate was computed to correct for multiple hypothesis testing and results passing FDR cutoff of 5% were accepted as significant. RESULTS: Mutations were mapped to amino acid changes for 3,733 non-silent mutations. Mutations correlated to mild outcome were located in the ORF8, NSP6, ORF3a, NSP4, and in the nucleocapsid phosphoprotein N. Mutations associated with inferior outcome were located in the surface (S) glycoprotein, in the RNA dependent RNA polymerase, in ORF3a, NSP3, ORF6 and N. Mutations leading to severe outcome with low prevalence were found in the ORF3A and in NSP7 proteins. Four out of 22 of the most significant mutations mapped onto a 10 amino acid long phosphorylated stretch of N indicating that in spite of obvious sampling restrictions the approach can find functionally relevant sites in the viral genome. CONCLUSIONS: We demonstrate that mutations in the viral genes may have a direct correlation to clinical outcome. Our results help to quickly identify SARS-CoV-2 infections harboring mutations related to severe outcome. |*COVID-19 Drug Treatment[MESH] |*Mutation[MESH] |COVID-19/*etiology[MESH] |Coronavirus Nucleocapsid Proteins/genetics[MESH] |Female[MESH] |Hospitalization[MESH] |Humans[MESH] |Male[MESH] |Mutation Rate[MESH] |SARS-CoV-2/*genetics[MESH] |Viral Nonstructural Proteins/genetics[MESH] |Viral Proteins/genetics[MESH]Different mutations in SARS-CoV-2 associate with severe and mild outco(epmc).pdf DeepDyve Pubget Overpricing